Sigma-1 receptors and neurodegenerative diseases: towards a hypothesis of sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection
Sigma-1 receptors are molecular chaperones that may act as pathological mediators and
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …
[HTML][HTML] Role of sigma-1 receptors in neurodegenerative diseases
Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes
appear to share common mechanisms of neuronal cellular dysfunction, including …
appear to share common mechanisms of neuronal cellular dysfunction, including …
Sigma receptors as potential therapeutic targets for neuroprotection
Sigma receptors comprise a unique family of proteins that have been implicated in the
pathophysiology and treatment of many central nervous system disorders, consistent with …
pathophysiology and treatment of many central nervous system disorders, consistent with …
[HTML][HTML] Neuronal sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
DA Ryskamp, S Korban, V Zhemkov… - Frontiers in …, 2019 - frontiersin.org
Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
Sigma-1 (σ1) Receptor in Memory and Neurodegenerative Diseases
T Maurice, N Goguadze - Sigma Proteins: Evolution of the Concept of …, 2017 - Springer
Abstract The sigma-1 (σ 1) receptor has been associated with regulation of intracellular Ca
2+ homeostasis, several cellular signaling pathways, and inter-organelle communication, in …
2+ homeostasis, several cellular signaling pathways, and inter-organelle communication, in …
[HTML][HTML] Sigma-1 receptor: the novel intracellular target of neuropsychotherapeutic drugs
T Hayashi - Journal of pharmacological sciences, 2015 - Elsevier
Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human
diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse …
diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse …
Bi-phasic dose response in the preclinical and clinical developments of sigma-1 receptor ligands for the treatment of neurodegenerative disorders
T Maurice - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
ABSTRACT Introduction: The sigma-1 receptor (S1R) is attracting much attention for disease-
modifying therapies in neurodegenerative diseases. It is a conserved protein, present in …
modifying therapies in neurodegenerative diseases. It is a conserved protein, present in …
[HTML][HTML] The involvement of the sigma-1 receptor in neurodegeneration and neurorestoration
K Ruscher, T Wieloch - Journal of pharmacological sciences, 2015 - Elsevier
Abstract The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …
Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain
JM Brimson, S Brimson, C Chomchoei… - Expert opinion on …, 2020 - Taylor & Francis
Introduction The sigma receptors are found abundantly in the central nervous system and
are targets for the treatment of various diseases, including Alzheimer's (AD), Parkinson's …
are targets for the treatment of various diseases, including Alzheimer's (AD), Parkinson's …
Targeting sigma receptors for the treatment of neurodegenerative and neurodevelopmental disorders
DS Malar, P Thitilertdecha, KS Ruckvongacheep… - CNS drugs, 2023 - Springer
The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …