Sigma-1 receptors are molecular chaperones that may act as pathological mediators and
targets for novel therapeutic applications in neurodegenerative diseases. Accumulating …

Neurodegenerative diseases with distinct genetic etiologies and pathological phenotypes
appear to share common mechanisms of neuronal cellular dysfunction, including …

Sigma receptors comprise a unique family of proteins that have been implicated in the
pathophysiology and treatment of many central nervous system disorders, consistent with …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Abstract The sigma-1 (σ 1) receptor has been associated with regulation of intracellular Ca
2+ homeostasis, several cellular signaling pathways, and inter-organelle communication, in …

Sigma-1 receptor ligands have been long expected to serve as drugs for treatment of human
diseases such as neurodegenerative disorders, depression, idiopathic pain, drug abuse …

ABSTRACT Introduction: The sigma-1 receptor (S1R) is attracting much attention for disease-
modifying therapies in neurodegenerative diseases. It is a conserved protein, present in …

Abstract The sigma-1 receptor (Sig-1R) is a single 25 kD polypeptide and a chaperone
protein immersed in lipid rafts of the endoplasmic reticulum (ER) where it interacts with …

Introduction The sigma receptors are found abundantly in the central nervous system and
are targets for the treatment of various diseases, including Alzheimer's (AD), Parkinson's …

The sigma-1 receptor is a 223 amino acid-long protein with a recently identified structure.
The sigma-2 receptor is a genetically unrelated protein with a similarly shaped binding …