Neurexin-1 alpha (NRXN1α) belongs to the family of cell adhesion molecules (CAMs), which
are involved in the formation of neuronal networks and synapses. NRXN1α gene mutations …

Neurexins are presynaptic transmembrane proteins crucial for synapse development and
organization. Deletion and missense mutations in all three Neurexin genes have been …

Over the past 3 decades, the prevalence of autism spectrum disorder (ASD) has increased
globally from 20 to 28 million cases making ASD the fastest-growing developmental …

Abstract 2p16. 3 deletion, involving NEUREXIN1 (NRXN1) heterozygous deletion,
substantially increases the risk of developing autism and other neurodevelopmental …

Increasing evidence suggests that abnormal synaptic function leads to neuronal
developmental disorders and is an important component of the etiology of autism spectrum …

Heterozygous mutations of the NRXN1 gene, which encodes the presynaptic cell-adhesion
molecule neurexin-1, were repeatedly associated with autism and schizophrenia. However …

Neurexins are central to trans-synaptic cell adhesion and signaling during synapse
specification and maintenance. The past two decades of human genetics research have …

Neurexins (Nrxns) have been extensively studied for their role in synapse organization and
have been linked to many neuropsychiatric disorders, including autism spectrum disorder …

Abstract Background Neurodevelopmental disorders (NDDs) are a group of disorders
induced by abnormal brain developmental processes. The prefrontal cortex (PFC) plays an …

Background NRXN1 deletions are identified as one of major rare risk factors for autism
spectrum disorder (ASD) and other neurodevelopmental disorders. ASD has 30% co …