Effect of genetic architecture on the prediction accuracy of quantitative traits in samples of unrelated individuals

F Morgante, W Huang, C Maltecca, TFC Mackay - Heredity, 2018 - nature.com
Predicting complex phenotypes from genomic data is a fundamental aim of animal and plant
breeding, where we wish to predict genetic merits of selection candidates; and of human …

Genomic Prediction for Quantitative Traits Is Improved by Mapping Variants to Gene Ontology Categories in Drosophila melanogaster

SM Edwards, IF Sørensen, P Sarup, TFC Mackay… - Genetics, 2016 - academic.oup.com
Predicting individual quantitative trait phenotypes from high-resolution genomic
polymorphism data is important for personalized medicine in humans, plant and animal …

Integrating nonadditive genomic relationship matrices into the study of genetic architecture of complex traits

A Nazarian, SA Gezan - Journal of Heredity, 2016 - academic.oup.com
The study of genetic architecture of complex traits has been dramatically influenced by
implementing genome-wide analytical approaches during recent years. Of particular interest …

Epistasis: obstacle or advantage for mapping complex traits?

KJF Verhoeven, G Casella, LM McIntyre - PloS one, 2010 - journals.plos.org
Identification of genetic loci in complex traits has focused largely on one-dimensional
genome scans to search for associations between single markers and the phenotype. There …

Improving accuracy of genomic prediction by genetic architecture based priors in a Bayesian model

N Gao, J Li, J He, G Xiao, Y Luo, H Zhang, Z Chen… - BMC genetics, 2015 - Springer
Background In recent years, with the development of high-throughput sequencing
technology and the commercial availability of genotyping bead chips, more attention is …

Using genetic distance to infer the accuracy of genomic prediction

M Scutari, I Mackay, D Balding - PLoS genetics, 2016 - journals.plos.org
The prediction of phenotypic traits using high-density genomic data has many applications
such as the selection of plants and animals of commercial interest; and it is expected to play …

GenoMatrix: a software package for pedigree-based and genomic prediction analyses on complex traits

A Nazarian, SA Gezan - Journal of Heredity, 2016 - academic.oup.com
Genomic and pedigree-based best linear unbiased prediction methodologies (G-BLUP and
P-BLUP) have proven themselves efficient for partitioning the phenotypic variance of …

Impact of linkage disequilibrium heterogeneity along the genome on genomic prediction and heritability estimation

D Ren, X Cai, Q Lin, H Ye, J Teng, J Li, X Ding… - Genetics Selection …, 2022 - Springer
Background Compared to medium-density single nucleotide polymorphism (SNP) data, high-
density SNP data contain abundant genetic variants and provide more information for the …

Genome-wide prediction of traits with different genetic architecture through efficient variable selection

V Wimmer, C Lehermeier, T Albrecht, HJ Auinger… - Genetics, 2013 - academic.oup.com
In genome-based prediction there is considerable uncertainty about the statistical model
and method required to maximize prediction accuracy. For traits influenced by a small …

Empirical and deterministic accuracies of across-population genomic prediction

YCJ Wientjes, RF Veerkamp, P Bijma… - Genetics Selection …, 2015 - Springer
Background Differences in linkage disequilibrium and in allele substitution effects of QTL
(quantitative trait loci) may hinder genomic prediction across populations. Our objective was …