Genetically targeted chemical assembly of functional materials in living cells, tissues, and animals
The structural and functional complexity of multicellular biological systems, such as the
brain, are beyond the reach of human design or assembly capabilities. Cells in living …
brain, are beyond the reach of human design or assembly capabilities. Cells in living …
Emergence of patterned stem cell differentiation within multicellular structures
SA Ruiz, CS Chen - Stem cells, 2008 - academic.oup.com
The ability of stem cells to differentiate into specified lineages in the appropriate locations is
vital to morphogenesis and adult tissue regeneration. Although soluble signals are important …
vital to morphogenesis and adult tissue regeneration. Although soluble signals are important …
Morphogen gradient reconstitution reveals Hedgehog pathway design principles
In developing tissues, cells estimate their spatial position by sensing graded concentrations
of diffusible signaling proteins called morphogens. Morphogen-sensing pathways exhibit …
of diffusible signaling proteins called morphogens. Morphogen-sensing pathways exhibit …
Monitoring of cell-cell communication and contact history in mammals
S Zhang, H Zhao, Z Liu, K Liu, H Zhu, W Pu, L He… - Science, 2022 - science.org
Monitoring of cell-cell communication in multicellular organisms is fundamental to
understanding diverse biological processes such as embryogenesis and tumorigenesis. To …
understanding diverse biological processes such as embryogenesis and tumorigenesis. To …
The importance of cell–cell interaction dynamics in bottom-up tissue engineering: concepts of colloidal self-assembly in the fabrication of multicellular architectures
Building tissue from cells as the basic building block based on principles of self-assembly is
a challenging and promising approach. Understanding how far principles of self-assembly …
a challenging and promising approach. Understanding how far principles of self-assembly …
Middle-out methods for spatiotemporal tissue engineering of organoids
MR Blatchley, KS Anseth - Nature Reviews Bioengineering, 2023 - nature.com
Organoids recapitulate many aspects of the complex three-dimensional (3D) organization
found within native tissues and even display tissue and organ-level functionality. Traditional …
found within native tissues and even display tissue and organ-level functionality. Traditional …
Adhesion-based self-organization in tissue patterning
Since the proposal of the differential adhesion hypothesis, scientists have been fascinated
by how cell adhesion mediates cellular self-organization to form spatial patterns during …
by how cell adhesion mediates cellular self-organization to form spatial patterns during …
Next-generation regenerative medicine: organogenesis from stem cells in 3D culture
Y Sasai - Cell stem cell, 2013 - cell.com
The behavior of stem cells, when they work collectively, can be much more sophisticated
than one might expect from their individual programming. This Perspective covers recent …
than one might expect from their individual programming. This Perspective covers recent …
Organs-on-a-chip models for biological research
G Vunjak-Novakovic, K Ronaldson-Bouchard… - Cell, 2021 - cell.com
We explore the utility of bioengineered human tissues—individually or connected into
physiological units—for biological research. While much smaller and simpler than their …
physiological units—for biological research. While much smaller and simpler than their …
Bioinspired materials for controlling stem cell fate
Although researchers currently have limited ability to mimic the natural stem cell
microenvironment, recent work at the interface of stem biology and biomaterials science has …
microenvironment, recent work at the interface of stem biology and biomaterials science has …