Animal tissue and organ development requires the orchestration of cell movements,
including those of interconnected cell groups, termed collective cell movements. Such …

Throughout biology, function is intimately linked with form. Across scales ranging from
subcellular to multiorganismal, the identity and organization of a biological structure's …

BACKGROUND: Inside the body, cells lie in direct contact or in close proximity to other cell
types in a tightly controlled architecture that often regulates the resulting tissue function …

Background Because of their differentiation potential, pluripotent stem cells can generate
virtually any cell type and, as such, can be used to model development and disease and …

Stem cell fate is influenced by a number of factors and interactions that require robust control
for safe and effective regeneration of functional tissue. Coordinated interactions with soluble …

The development of neural circuits involves wiring of neurons locally following their
generation and migration, as well as establishing long-distance connections between brain …

Embryoids and organoids hold great promise for human biology and medicine. Herein, we
discuss conceptual and technological frameworks useful for developing high-fidelity …

In multicellular organisms, gene regulatory circuits generate thousands of molecularly
distinct, mitotically heritable states through the property of multistability. Designing synthetic …

Multicellular organisms generate tissues of diverse shapes and functions from cells and
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …