A new era of biological engineering is emerging in which living cells are used as building
blocks to address therapeutic challenges. These efforts are distinct from traditional …

Supramolecular assemblies are essential components of living organisms. Cellular
scaffolds, such as the cytoskeleton or the cell membrane, are formed via secondary …

Tissue morphogenesis is strikingly robust. Yet, how tissues are sculpted under challenging
conditions is unknown. Here, we combined network analysis, experimental perturbations …

In vitro-generated tissues hold significant promise in modern biology since they can
potentially mimic physiological and pathological tissues. However, these are currently …

Embryo development requires biochemical signalling to generate patterns of cell fates and
active mechanical forces to drive tissue shape changes. However, how these processes are …

Living cells communicate and cooperate to produce the emergent properties of tissues.
Synthetic mimics of cells, such as liposomes, are typically incapable of cooperation and …

Complex tissues contain multiple cell types that are hierarchically organized within
morphologically and functionally distinct compartments. Construction of engineered tissues …

Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and
are largely a product of the varied functions of adherens junctions. These junctions and their …

INTRODUCTION Synthetic biology applies engineering methodologies to biology to build
new functions into living cells. Through the assembly and characterization of engineered …

Self-assembly is a fundamental process that drives structural organization in both inanimate
and living systems. It is in the course of self-assembly of cells and tissues in early …