Levels of autonomy in synthetic biology engineering

J Beal, M Rogers - Molecular systems biology, 2020 - embopress.org
Engineering biological organisms is a complex, challenging, and often slow process. Other
engineering domains have addressed such challenges with a combination of …

[HTML][HTML] Developments in the tools and methodologies of synthetic biology

R Kelwick, JT MacDonald, AJ Webb… - … in bioengineering and …, 2014 - frontiersin.org
Synthetic biology is principally concerned with the rational design and engineering of
biologically based parts, devices, or systems. However, biological systems are generally …

Bio-design automation: software+ biology+ robots

DM Densmore, S Bhatia - Trends in biotechnology, 2014 - cell.com
Synthetic biology promises to usher in a new era of scientific innovation and discovery [1].
Applicationsof thistechnology are broad and diverse [2]. Although applications frequently …

Engineering microbes with synthetic biology frameworks

E Leonard, D Nielsen, K Solomon, KJ Prather - Trends in biotechnology, 2008 - cell.com
Typically, the outcome of biologically engineered unit operations cannot be controlled a
priori due to the incorporation of ad hoc design into complex natural systems. To mitigate …

[HTML][HTML] Bridging the gap: a roadmap to breaking the biological design barrier

J Beal - Frontiers in bioengineering and biotechnology, 2015 - frontiersin.org
This paper presents an analysis of an emerging bottleneck in organism engineering, and
paths by which it may be overcome. Recent years have seen the development of a profusion …

Synthetic biology: an emerging engineering discipline

AA Cheng, TK Lu - Annual review of biomedical engineering, 2012 - annualreviews.org
Over the past decade, synthetic biology has emerged as an engineering discipline for
biological systems. Compared with other substrates, biology poses a unique set of …

Functional synthetic biology

I Aldulijan, J Beal, S Billerbeck, J Bouffard… - Synthetic …, 2023 - academic.oup.com
Synthetic biologists have made great progress over the past decade in developing methods
for modular assembly of genetic sequences and in engineering biological systems with a …

[HTML][HTML] Informing biological design by integration of systems and synthetic biology

CD Smolke, PA Silver - Cell, 2011 - cell.com
Synthetic biology aims to make the engineering of biology faster and more predictable. In
contrast, systems biology focuses on the interaction of myriad components and how these …

Engineering reduced evolutionary potential for synthetic biology

BA Renda, MJ Hammerling, JE Barrick - Molecular BioSystems, 2014 - pubs.rsc.org
The field of synthetic biology seeks to engineer reliable and predictable behaviors in
organisms from collections of standardized genetic parts. However, unlike other types of …

[PDF][PDF] TASBE: A tool-chain to accelerate synthetic biological engineering

J Beal, R Weiss, D Densmore, A Adler, J Babb… - Proceedings of the 3rd …, 2011 - Citeseer
There is a pressing need for design automation tools for synthetic biology systems.
Compared to electronic circuits, cellular information processing has more complex …