Alcohol consumption is a predominant etiological factor in the pathogenesis of chronic liver
diseases worldwide, causing fatty liver, alcoholic hepatitis, fibrosis/cirrhosis, and …

Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

Background & Aims Binge drinking in patients with metabolic syndrome accelerates the
development of alcohol-associated liver disease. However, the underlying mechanisms …

A joint meeting of the European Association for the Study of the Liver (EASL) and the
American Association for the Study of Liver Diseases (AASLD) was held in London on …

Growing evidence indicates that the innate immune system and oxidative stress caused by
gutderived endotoxins play a key role in alcoholic liver disease (ALD). Intracellular …

Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

Obesity potentiates the severity of alcohol-induced liver damage. Ethanol influences
adipose tissue production of hormones and cytokines. The mechanisms by which adiposity …

Heavy alcohol consumption over long periods of time can result in severe liver damage,
including death of liver cells (ie, hepatocytes). Two mechanisms—apoptosis and necrosis …

Alcoholic liver injury involves a complex array of derangements in cellular signaling of
hepatic parenchymal and nonparenchymal cells as well as cells of the immune system. In …

Chronic alcohol abuse is an important cause of morbidity and mortality throughout the world.
Liver damage due to chronic alcohol intoxication initially leads to accumulation of lipids …