Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis

SK Ramaiah, C Rivera… - International Journal of …, 2004 - journals.sagepub.com
Alcoholic liver disease (ALD) remains to be one of the most common etiology of liver
disease and is a major cause of morbidity and mortality worldwide. The pathologic stages of …

Pathogenesis of alcoholic liver disease: newer mechanisms of injury

DW Crabb - The Keio journal of medicine, 1999 - jstage.jst.go.jp
The understanding of how alcohol damages the liver has expanded substantially over the
last decade. In particular, the genetics of alcoholism, the genesis of fatty liver, the role of …

[HTML][HTML] Alcoholic liver disease: pathogenesis and current management

NA Osna, TM Donohue Jr… - Alcohol research: current …, 2017 - ncbi.nlm.nih.gov
Excessive alcohol consumption is a global healthcare problem. The liver sustains the
greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol …

Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage

MG Neuman, SW French, S Zakhari, S Malnick… - … and molecular pathology, 2017 - Elsevier
This paper is based upon the “8th Charles Lieber's Satellite Symposium” organized by
Manuela G. Neuman at the Research Society on Alcoholism Annual Meeting, on June 25 …

A unifying hypothesis linking hepatic adaptations for ethanol metabolism to the proinflammatory and profibrotic events of alcoholic liver disease

Z Zhong, JJ Lemasters - Alcoholism: Clinical and Experimental …, 2018 - Wiley Online Library
The pathogenesis of alcoholic liver disease (ALD) remains poorly understood but is likely a
multihit pathophysiological process. Here, we propose a hypothesis of how early …

Current medical treatment for alcohol-associated liver disease

G Ayares, F Idalsoaga, LA Díaz, J Arnold… - Journal of Clinical and …, 2022 - Elsevier
Alcohol-associated liver disease is one of the main causes of chronic liver disease. It
comprises a clinical-histologic spectrum of presentations, from steatosis, steatohepatitis, to …

Alcohol and the liver

A Reuben - Current opinion in gastroenterology, 2008 - journals.lww.com
Alcohol and the liver : Current Opinion in Gastroenterology Alcohol and the liver : Current
Opinion in Gastroenterology Log in or Register Subscribe to journalSubscribe Get new issue …

The management of alcoholic liver disease

SF Stewart, CP Day - Journal of hepatology, 2003 - Elsevier
Alcoholic liver disease (ALD) is the commonest cause of cirrhosis in the Western world,
currently one of the ten most common causes of death [1]. Deaths from cirrhosis rose with …

Mechanisms of alcoholic liver injury

SW French - Canadian Journal of Gastroenterology and …, 2000 - Wiley Online Library
There have been numerous recent advances in the understanding of the mechanisms of
alcoholic liver disease pathogenesis. Endotoxin‐induced Kupffer cell activation plays a role …

Acetaldehyde adducts in alcoholic liver disease

M Setshedi, JR Wands… - Oxidative medicine and …, 2010 - Wiley Online Library
Chronic alcohol abuse causes liver disease that progresses from simple steatosis through
stages of steatohepatitis, fibrosis, cirrhosis, and eventually hepatic failure. In addition …