Mammalian tissues express the cannabinoid 1 (CB1) receptor and the cannabinoid 2 (CB2)
receptor, the latter being involved in inflammation and pain. In somatic nerve pathways, the …

Background Experimental evidence suggests the endogenous cannabinoid system may
protect against colonic inflammation, leading to the possibility that activation of this system …

Highlights•The endocannabinoid system (ECS) is dysregulated in obesity-associated
diseases.•CB 1 antagonism is a potential therapeutic target for the treatment of obesity.•CB 1 …

The endocannabinoid (EC) system consists of two main receptors: cannabinoid type 1
receptor cannabinoid receptors are found in both the central nervous system (CNS) and …

The discovery of endogenous cannabinoid receptors CB1 and CB2 and their endogenous
ligands has generated interest in the endocannabinoid system and has contributed to the …

Background & Aims Cannabis (delta-9-tetrahydrocannabinol), a nonselective cannabinoid-
receptor agonist, relieves nausea and pain. Cannabidiol (CBD), a cannabinoid receptor 2 …

Understanding how the body regulates pain is fundamental to develop rational strategies to
combat the growing prevalence of chronic pain states, opioid dependency, and the …

The endocannabinoid system plays an important role in the control of emotions, and its
dysregulation has been implicated in several psychiatric disorders. The most common self …

Aims Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder, associated
with alterations of bowel function, abdominal pain and other symptoms related to the GI tract …

Pain is a highly unpleasant and intolerable condition, which is associated with multiple
diseases and disorders, including but not limited to cancer, diabetes, infectious diseases …