The endocannabinoid (eCB) system is a widespread intercellular signalling mechanism that
plays a critical role in body homoeostasis. It is located in key points involved in food intake …

The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal
barrier function and immune regulation are key determinants of intestinal homeostasis and …

Background & Aims: Two G-protein—coupled cannabinoid receptors, termed CB1 and CB2,
have been identified and several mammalian enteric nervous systems express CB1 …

Abstract Background and Aims The gut immune, cannabinoid, and opioid systems constitute
an integrated network contributing to visceral sensation and pain modulation. We aimed to …

Background Clinical trials investigating the use of cannabinoid drugs for the treatment of
intestinal inflammation are anticipated secondary to preclinical literature demonstrating …

The enteric nervous system (ENS) is a part of the autonomic nervous system that intrinsically
innervates the gastrointestinal (GI) tract. Whereas enteric neurons have been deeply …

The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …

A multitude of physiological effects and putative pathophysiological roles have been
proposed for the endogenous cannabinoid system in the gastrointestinal tract, liver and …

Δ9‐Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and
synthetic cannabinoids, exert many biological functions by activating two types of …

Abdominal pain is a key symptom of inflammatory bowel disease and irritable bowel
syndrome, for which there are inadequate therapeutic options. We tested whether olorinab …