Antidepressant discontinuation symptoms occur with all classes of antidepressant. A well-
described discontinuation syndrome occurs with the selective serotonin reuptake inhibitors …

The aim of this article is to discuss the validity of relapse prevention trials and the issue of
withdrawal confounding in these trials. Recommendations for long-term antidepressant …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

BackgroundAlthough the efficacy of antidepressants has been demonstrated in randomised,
controlled clinical trials, it is how an antidepressant is used in clinical practice that …

Background Many members of the public have negative attitudes towards antidepressants.
Psychological interventions are more acceptable but require considerable therapist training …

Objectives: To examine the available scientific literature for answers to clinically relevant
questions regarding the effectiveness and tolerability of antidepressant drugs (ADs) for the …

Background: Stopping antidepressants is often difficult due to withdrawal. Taperingstrips
were developed to facilitate antidepressant discontinuation according to the recently …

Bschor T, Baethge C. No evidence for switching the antidepressant: systematic review and
meta‐analysis of RCTs of a common therapeutic strategy. Objective: Switching …

Background: Current guidelines for antidepressant prescribing are that treatment should be
continued following the resolution of symptoms: six months after a first episode and for at …

A significant clinical issue encountered after a successful acute major depressive disorder
(MDD) treatment is the relapse of depressive symptoms. Although continuing maintenance …