Background It is common for people not to take antidepressant medication as prescribed,
with around 50% of people likely to prematurely discontinue taking their medication after six …

Objective: To examine the available scientific evidence for answers to clinically relevant
questions on the effectiveness and tolerability of antidepressant drugs (ADs) for the long …

Strong evidence supports the existence of a discontinuation syndrome following the
withdrawal of antidepressant medication, particularly second-generation antidepressants …

Background: The large majority of depressed patients fail to remit on the first antidepressant
prescribed. These patients with residual symptoms have higher relapse rates and poorer …

Background: Long-term antidepressant use has increased exponentially, though this is not
always according to guidelines. Our previous randomized controlled trial (RCT) showed that …

Background Many people experience withdrawal symptoms when they attempt to stop
antidepressants. Withdrawal symptoms are readily misconstrued for relapse or ongoing …

To minimize the symptoms of antidepressant discontinuation, gradual tapering is necessary
for all serotonin reuptake inhibitors (SRIs) except fluoxetine, which has an extended half-life …

Depression is the most frequent and costly problem in primary care, where most of these
patients are seen and treated. In many countries, the public regard antidepressant drugs as …

Introduction Depressive disorders are the most common, burdensome and costly mental
disorders. Their treatments have developed through the past decades and we now have …

Introduction Pharmacotherapy plays an important role in the treatment of major depression.
At the initiation of antidepressant treatment, both improvement of symptoms in the short term …