Depression is a common and serious mental illness which is treated mainly in primary care
settings. The most common treatment modality is antidepressant medication. Controlled …

Objective Our aim was to explore general practitioners'(GPs) perceptions and experiences
of discontinuing antidepressants. Study design A qualitative study using semistructured …

Twenty eight patients treated with selective serotonin reuptake inhibitors/venlafaxine were
randomized to a three-day (short) or 14-day (longer) anti—depressant taper and openly …

If a patient with major depressive disorder has not responded after an adequate trial of an
antidepressant medication, switching to another antidepressant of the same class or a …

Background Although antidepressants are often a first‐line treatment for adults with
moderate to severe depression, many people do not respond adequately to medication, and …

Objective: Non-response to antidepressant treatment is a substantial problem in primary
care, and many patients with depression require additional second-line treatments. This …

This clinical guideline on depression is an updated edition of the previous guidance
(published in 2004). It was commissioned by NICE and developed by the National …

BackgroundAfter remission, antidepressants are often taken long term to prevent depressive
relapse or recurrence. Whether psychological interventions can be a viable alternative or …

Objective: Continuation therapy with antidepressants is recommended for depressed
patients who have responded to initial treatment. We quantified its efficacy in preventing …

Objective: To evaluate the efficacy and tolerability of dose increase compared to dose
continuation of the initially prescribed antidepressant in antidepressant treatment failure …