For centuries, regeneration observed in organisms such as amphibians and crustaceans
has fueled enthusiasm for the potential of regenerative medicine. The ability to recreate …

The paper “Bladder Augmentation using Allogenic Bladder Submucosa Seeded with Cells,”
published in 1998, is the first journal article in the biomedical field describing the …

The treatment of end-stage organ failure by transplantation remains limited by shortages of
donors and immune rejection without suppressive therapy. The development of artificial …

A bstract Bladder wall replacement is one of the most challenging problems of urologic
surgery. Various materials have been tried in experimental models, but most were not free of …

CURRENT clinical strategies to augment or reconstruct dysfunctional bladders rely on the
use of intestine as a tissue substitute. Although this has been the standard protocol for …

Substantial clinical need persists for improved autologous tissues to augment or replace the
urinary bladder, and research has begun to address this using tissue engineering …

Results Numerous studies to develop a substitute for the native urinary bladder wall us-ing
the tissue engineering approach are ongoing. Stem cells combined with biomaterials open …

The fusion of engineering with cell biology and advances in biomaterials may lead to de
novo construction of implantable organs. Engineering of neobladder from autologous …

Tissue or organ loss resulting from traumatic or non-traumatic destruction causes major
health problems, severely affecting patient's quality and length of life. Traditionally surgical …

There are a number of conditions of the bladder that can lead to loss of function. Many of
these require reconstructive procedures. However, current techniques may lead to a number …