Heparin, a sulfated polysaccharide, is a major clinical anticoagulant. It is exploited to
overcome the natural propensity for blood to clot. Surgical procedures often require …

Heparin is a highly sulfated linear poly-saccharide that was discovered in 1916 as an
anticoagulant and has been used clinically since 1935 (see ref. 1 for review). The …

The sulfated polysaccharide heparin has been used as a life-saving anticoagulant in clinics
well before its detailed structure was known. This mini-review is a survey of the evolution in …

Issues of nomenclature are rarely inspiring; the main emphasis of this presentation will in
fact be on the biosynthesis rather than on the designation of" heparin-like polysaccharides" …

The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been
and continue to be a major scientific undertaking-heparin and its derivative remain important …

Publisher Summary This chapter discusses the structural aspects and structure–activity
relationships of heparin/heparan sulfate (HS). The molecular mechanism behind the …

Heparin has been used extensively in the clinical setting as an anticoagulant. The properties
of this polymer were first noted by McLean during his second year as a medical student at …

The history of heparin is described from its initial discovery in 1916 to recent developments
in knowledge of its mechanism of action and clinical use. Commercial production started …

The glycosaminoglycan heparin has been used in the clinic as an anticoagulant for more
than 50 years. A fully characterized sequence in native heparin is known to be responsible …

Heparin is a glycosaminoglycuran that is widely distributed in animal tissues. It is composed
of an alternating sequence of 2-amino-2-deoxy sugars and hexuronic acids,'usually …