Characterization of operant social interaction in rats: effects of access duration, effort, peer familiarity, housing conditions, and choice between social interaction vs …

JJ Chow, NJ Beacher, JM Chabot, M Oke… - …, 2022 - Springer
Rationale and objective Social factors play a critical role in drug addiction. We recently
showed that rats will abstain from methamphetamine, cocaine, heroin, and remifentanil self …

Operant social reward decreases incubation of heroin craving in male and female rats

M Venniro, TI Russell, M Zhang, Y Shaham - Biological psychiatry, 2019 - Elsevier
Background We recently reported that operant social choice–induced voluntary abstinence
prevents incubation of methamphetamine craving. Here, we determined whether social …

The two faces of social interaction reward in animal models of drug dependence

R El Rawas, A Saria - Neurochemical research, 2016 - Springer
Drug dependence is a serious health and social problem. Social factors can modify
vulnerability to developing drug dependence, acting as risk factors or protective factors …

An operant social self-administration and choice model in rats

M Venniro, Y Shaham - Nature protocols, 2020 - nature.com
It is difficult to translate results from animal research on addiction to an understanding of the
behavior of human drug users. Despite decades of basic research on neurobiological …

The protective effect of operant social reward on cocaine self-administration, choice, and relapse is dependent on delay and effort for the social reward

M Venniro, LV Panlilio, DH Epstein… - …, 2021 - nature.com
Social reinforcement-based treatments are effective for many, but not all, people with
addictions to drugs. We recently developed an operant rat model that mimics features of one …

Sensitivity of a fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations

CMS Onge, KM Taylor, MM Marcus… - Pharmacology …, 2022 - Elsevier
Recent studies have shown that social interaction can serve as an alternative reinforcer to
opioid self-administration under a choice context in rats. However, additional parametric …

[HTML][HTML] Social contact reinforces cocaine self-administration in young adult male rats: The role of social reinforcement in vulnerability to drug use

MA Smith, HS Cha, AK Griffith, JL Sharp - Frontiers in Behavioral …, 2021 - frontiersin.org
Drug-using peers are recognized as a leading factor influencing drug use among
adolescents and young adults. One mechanism by which peers influence drug use is by …

Animal models of social contact and drug self-administration

JC Strickland, MA Smith - Pharmacology Biochemistry and Behavior, 2015 - Elsevier
Social learning theories of drug abuse propose that individuals imitate drug use behaviors
modeled by social peers, and that these behaviors are selectively reinforced and/or …

[HTML][HTML] Operant social self-administration in male CD1 mice

SS Lee, M Venniro, Y Shaham, BT Hope… - …, 2024 - Springer
Abstract Rationale and Objective We recently introduced a model of operant social reward in
which female CD1 mice lever press for access to affiliative social interaction with a …

Rats choose alcohol over social reward in an operant choice procedure

NJ Marchant, AJ McDonald, R Matsuzaki… - …, 2023 - nature.com
The interaction between social factors and alcohol addiction is complex, with potential for
both positive and negative contributions to drug use and abstinence. Positive social …