PU. 1 target genes undergo Tet2-coupled demethylation and DNMT3b-mediated methylation in monocyte-to-osteoclast differentiation
Background DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-
fate decisions. Local deposition and removal of DNA methylation are tightly coupled with …
fate decisions. Local deposition and removal of DNA methylation are tightly coupled with …
Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites
A Hogart, J Lichtenberg, SS Ajay, S Anderson… - Genome …, 2012 - genome.cshlp.org
DNA methylation is an essential epigenetic mark that is required for normal development.
Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment …
Knockout of the DNA methyltransferase enzymes in the mouse hematopoietic compartment …
Dynamic changes in the human methylome during differentiation
DNA methylation is a critical epigenetic regulator in mammalian development. Here, we
present a whole-genome comparative view of DNA methylation using bisulfite sequencing of …
present a whole-genome comparative view of DNA methylation using bisulfite sequencing of …
Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys
Background Previous studies showed that the majority of developmental genes are devoid
of DNA methylation at promoters even when they are repressed. Such hypomethylated …
of DNA methylation at promoters even when they are repressed. Such hypomethylated …
DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway
K Nishikawa, Y Iwamoto, Y Kobayashi, F Katsuoka… - Nature medicine, 2015 - nature.com
Metabolic reprogramming occurs in response to the cellular environment to mediate
differentiation,,, but the fundamental mechanisms linking metabolic processes to …
differentiation,,, but the fundamental mechanisms linking metabolic processes to …
Genome‐wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
J Delgado‐Calle, AF Fernández, J Sainz… - Arthritis & …, 2013 - Wiley Online Library
Objective To determine genome‐wide methylation profiles of bone from patients with hip
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …
osteoarthritis (OA) and those with osteoporotic (OP) hip fractures. Methods Trabecular bone …
[HTML][HTML] DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism
Osteoarthritis (OA) is the most common form of arthritis worldwide. It is a complex disease
affecting the whole joint but is generally characterized by progressive degradation of …
affecting the whole joint but is generally characterized by progressive degradation of …
WTAP-mediated m6A RNA methylation regulates the differentiation of bone marrow mesenchymal stem cells via the miR-29b-3p/HDAC4 axis
J Liu, Y You, Z Sun, L Zhang, X Li, Z Dai… - Stem Cells …, 2023 - academic.oup.com
Abstract N6-methyladenosine (m6A) methylation, a well-known modification with new
epigenetic functions, has been reported to participate in the progression of osteoporosis …
epigenetic functions, has been reported to participate in the progression of osteoporosis …
A comparative analysis of DNA methylation across human embryonic stem cell lines
Background We performed a comparative analysis of the genome-wide DNA methylation
profiles from three human embryonic stem cell (HESC) lines. It had previously been shown …
profiles from three human embryonic stem cell (HESC) lines. It had previously been shown …
DNA methylation disruption reshapes the hematopoietic differentiation landscape
Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A)
are frequently observed in hematological malignancies,–and clonal hematopoiesis …
are frequently observed in hematological malignancies,–and clonal hematopoiesis …