Predicting the impact of non-coding variants on DNA methylation
H Zeng, DK Gifford - Nucleic acids research, 2017 - academic.oup.com
DNA methylation plays a crucial role in the establishment of tissue-specific gene expression
and the regulation of key biological processes. However, our present inability to predict the …
and the regulation of key biological processes. However, our present inability to predict the …
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
DN Weinberg, S Papillon-Cavanagh, H Chen, Y Yue… - Nature, 2019 - nature.com
Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1
(DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue …
(DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue …
TET proteins safeguard bivalent promoters from de novo methylation in human embryonic stem cells
Abstract TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC),
which can lead to DNA demethylation. However, direct connections between TET-mediated …
which can lead to DNA demethylation. However, direct connections between TET-mediated …
Deep sequencing and de novo assembly of the mouse oocyte transcriptome define the contribution of transcription to the DNA methylation landscape
Background Previously, a role was demonstrated for transcription in the acquisition of DNA
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
methylation at imprinted control regions in oocytes. Definition of the oocyte DNA methylome …
An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)
We report a novel resource (m ethylation p rofiles of D NA, or mPod) for human genome-
wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts …
wide tissue-specific DNA methylation profiles. mPod consists of three fully integrated parts …
Homeobox oncogene activation by pan-cancer DNA hypermethylation
Background Cancers have long been recognized to be not only genetically but also
epigenetically distinct from their tissues of origin. Although genetic alterations underlying …
epigenetically distinct from their tissues of origin. Although genetic alterations underlying …
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver
AL Brunner, DS Johnson, SW Kim, A Valouev… - Genome …, 2009 - genome.cshlp.org
To investigate the role of DNA methylation during human development, we developed
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …
Methyl-seq, a method that assays DNA methylation at more than 90,000 regions throughout …
Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms
Background Epigenetic change is a hallmark of ageing but its link to ageing mechanisms in
humans remains poorly understood. While DNA methylation at many CpG sites closely …
humans remains poorly understood. While DNA methylation at many CpG sites closely …
H3K36 dimethylation shapes the epigenetic interaction landscape by directing repressive chromatin modifications in embryonic stem cells
Epigenetic modifications on the chromatin do not occur in isolation. Chromatin-associated
proteins and their modification products form a highly interconnected network, and …
proteins and their modification products form a highly interconnected network, and …
Simultaneous profiling of transcriptome and DNA methylome from a single cell
Background Single-cell transcriptome and single-cell methylome technologies have become
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …
powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide …