Copy number alteration burden predicts prostate cancer relapse
H Hieronymus, N Schultz, A Gopalan… - Proceedings of the …, 2014 - National Acad Sciences
Primary prostate cancer is the most common malignancy in men but has highly variable
outcomes, highlighting the need for biomarkers to determine which patients can be …
outcomes, highlighting the need for biomarkers to determine which patients can be …
Tumor copy number alteration burden is a pan-cancer prognostic factor associated with recurrence and death
The level of copy number alteration (CNA), termed CNA burden, in the tumor genome is
associated with recurrence of primary prostate cancer. Whether CNA burden is associated …
associated with recurrence of primary prostate cancer. Whether CNA burden is associated …
[HTML][HTML] Integration of copy number and transcriptomics provides risk stratification in prostate cancer: a discovery and validation cohort study
Background Understanding the heterogeneous genotypes and phenotypes of prostate
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
cancer is fundamental to improving the way we treat this disease. As yet, there are no …
Whole-genome and transcriptome sequencing of prostate cancer identify new genetic alterations driving disease progression
Background Global disparities in prostate cancer (PCa) incidence highlight the urgent need
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
to identify genomic abnormalities in prostate tumors in different ethnic populations including …
Whole genome scanning identifies genotypes associated with recurrence and metastasis in prostate tumors
PL Paris, A Andaya, J Fridlyand, AN Jain… - Human molecular …, 2004 - academic.oup.com
Prostate cancer is the most commonly diagnosed non-cutaneous neoplasm among
American males and is the second leading cause of cancer-related death. Prostate specific …
American males and is the second leading cause of cancer-related death. Prostate specific …
Prospective genomic profiling of prostate cancer across disease states reveals germline and somatic alterations that may affect clinical decision making
Purpose A long natural history and a predominant osseous pattern of metastatic spread are
impediments to the adoption of precision medicine in patients with prostate cancer. To …
impediments to the adoption of precision medicine in patients with prostate cancer. To …
Genetic markers associated with early cancer‐specific mortality following prostatectomy
W Liu, CC Xie, CY Thomas, ST Kim, J Lindberg… - Cancer, 2013 - Wiley Online Library
BACKGROUND This study sought to identify novel effectors and markers of localized but
potentially life‐threatening prostate cancer (PCa), by evaluating chromosomal copy number …
potentially life‐threatening prostate cancer (PCa), by evaluating chromosomal copy number …
[HTML][HTML] Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
Background Patients with prostate cancer may present with metastatic or recurrent disease
despite initial curative treatment. The propensity of metastatic prostate cancer to spread to …
despite initial curative treatment. The propensity of metastatic prostate cancer to spread to …
[PDF][PDF] The proteogenomic landscape of curable prostate cancer
DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
Aneuploidy drives lethal progression in prostate cancer
KH Stopsack, CA Whittaker, TA Gerke… - Proceedings of the …, 2019 - National Acad Sciences
Aneuploidy, defined as chromosome gains and losses, is a hallmark of cancer. However,
compared with other tumor types, extensive aneuploidy is relatively rare in prostate cancer …
compared with other tumor types, extensive aneuploidy is relatively rare in prostate cancer …
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