[HTML][HTML] Deep coverage whole genome sequences and plasma lipoprotein (a) in individuals of European and African ancestries

SM Zekavat, S Ruotsalainen, RE Handsaker… - Nature …, 2018 - nature.com
Abstract Lipoprotein (a), Lp (a), is a modified low-density lipoprotein particle that contains
apolipoprotein (a), encoded by LPA, and is a highly heritable, causal risk factor for …

[HTML][HTML] Single-Nucleotide Polymorphisms in LPA Explain Most of the Ancestry-Specific Variation in Lp(a) Levels in African Americans

RC Deo, JG Wilson, C Xing, K Lawson, WHL Kao… - PloS one, 2011 - journals.plos.org
Lipoprotein (a)(Lp (a)) is an important causal cardiovascular risk factor, with serum Lp (a)
levels predicting atherosclerotic heart disease and genetic determinants of Lp (a) levels …

[HTML][HTML] Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

J Li, LA Lange, J Sabourin, Q Duan, W Valdar… - Journal of human …, 2015 - nature.com
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …

[HTML][HTML] A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region [S]

S Coassin, S Schönherr, H Weissensteiner… - Journal of lipid …, 2019 - ASBMB
Lipoprotein (a)[Lp (a)] concentrations are among the strongest genetic risk factors for
cardiovascular disease and present pronounced interethnic and interindividual differences …

Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians

MB Lanktree, SS Anand, S Yusuf… - Circulation …, 2010 - Am Heart Assoc
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …

[HTML][HTML] A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]

S Mack, S Coassin, R Rueedi, NA Yousri… - Journal of lipid …, 2017 - ASBMB
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …

[HTML][HTML] Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein (a) in 10,910 individuals

S Di Maio, R Grüneis, G Streiter, C Lamina… - Genome medicine, 2020 - Springer
Background The concentrations of the highly atherogenic lipoprotein (a)[Lp (a)] are mainly
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …

[HTML][HTML] Genome-wide association study of plasma lipoprotein (a) levels identifies multiple genes on chromosome 6q [S]

C Ober, AS Nord, EE Thompson, L Pan, Z Tan… - Journal of lipid …, 2009 - ASBMB
Plasma lipoprotein (a)(Lp [a]) level is an independent risk factor of cardiovascular disease
that is under strong genetic control. We conducted a genome-wide association study of …

Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report

M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …

Associations of genetically predicted Lp (a)(lipoprotein [a]) levels with cardiovascular traits in individuals of European and African Ancestry

BA Satterfield, O Dikilitas, MS Safarova… - Circulation: Genomic …, 2021 - Am Heart Assoc
Background: Lp (a)(lipoprotein [a]) levels are higher in individuals of African ancestry (AA)
than in individuals of European ancestry (EA). We examined associations of genetically …