Background—Although epidemiological studies have demonstrated an increased
predisposition to low high-density lipoprotein cholesterol and high triglyceride levels in the …

Background: The clinical implications of a polygenic risk score (PRS) for LDL-C (low-density
lipoprotein cholesterol) are not well understood, both within the general population and …

Background Low concentrations of lipoprotein (a) in plasma are associated with increased
risk of type 2 diabetes, but whether this association is causal is unclear. Variations in the …

Objectives: The purpose of this study is investigate the effects of variants in the
apolipoprotein (a) gene (LPA) on vascular diseases with different atherosclerotic and …

Objective: Lp (a)(lipoprotein [a]) concentrations are associated with atherosclerotic
cardiovascular disease (ASCVD), and new therapies that enable potent and specific …

A genome-wide association study (GWAS) of 94,674 ancestrally diverse Kaiser Permanente
members using 478,866 longitudinal electronic health record (EHR)-derived measurements …

Rare genetic variants, identified by in-detail resequencing of loci, may contribute to complex
traits. We used the apolipoprotein AI gene (APOA1), a major high-density lipoprotein (HDL) …

Rates of atherosclerotic cardiovascular diseases (CVD) in the Western world have
spectacularly decreased over the past 50 years. However, a substantial proportion of high …

Background: Plasma lipid levels are heritable and genetically associated with risk of
coronary artery disease (CAD). However, genome-wide association studies (GWAS) …

Most studies aiming to detect associations of genetic variation with common complex
diseases, eg coronary heart disease (CHD) have been performed in populations with a …