New strategies for the treatment of breast cancer with lepto... : Current Opinion in Oncology
New strategies for the treatment of breast cancer with leptomeningeal metastasis : Current …

Leptomeningeal metastases (LM) presents a challenge because of the difficulty in
determining the diagnosis and lack of optimal therapy. Nowadays, LM are more frequently …

Clinical data supporting the best therapeutic approach in leptomeningeal disease (LMD;
also known as leptomeningeal metastases or leptomeningeal carcinomatosis) are lacking …

Leptomeningeal metastasis (LM), which occurs when malignant cells spread to the central
nervous system, is becoming an increasingly common complication in patients with breast …

Leptomeningeal metastasis (LM) in breast cancer patients confers a uniformly poor
prognosis and decreased quality of life. Treatment options are limited and often ineffective …

Purpose Leptomeningeal disease (LMD) is an uncommon complication of advanced breast
cancer. The prognosis is poor, and although radiotherapy (RT), systemic and intra-thecal (IT) …

Background There is limited data on the impact of specific patient characteristics, tumor
subtypes or treatment interventions on survival in breast cancer LM. Methods A systematic …

Aim The aim of the study was to assess the efficacy of multimodality treatment of patients
with Leptomeningeal metastasis (LM) and to establish which method of treatment has the …

Background/Aim: Prolonged overall survival (OS) has been reported for selected patients
with leptomeningeal metastases (LM). The management and treatment of such patients is …

Approximately 5% of breast cancer patients develop leptomeningeal metastases over the
course of their disease. Though several treatments options are available for these patients …