Matricellular proteins have been classified as a family of non-structural matrix proteins
capable of modulating a variety of biological processes within the extracellular matrix (ECM) …

The multistep process of metastasis is a major hallmark of cancer progression involving the
cointeraction and coevolution of the tumor and its microenvironment. In the tumor …

The extracellular matrix (ECM) plays a crucial role in regulating organ homeostasis. It
provides mechanical and biochemical cues directing cellular behaviour and, therefore, has …

The extracellular matrix (ECM) surrounding cells is indispensable for regulating their
behavior. The dynamics of ECM signaling are tightly controlled throughout growth and …

The family of matricellular proteins comprises molecules with disparate biology. The main
characteristic of matricellular proteins is to be expressed during tissue renewal and repair in …

Tumor progression and dissemination critically depend on support from the tumor
microenvironment, the ensemble of cellular and acellular components surrounding and …

Simple Summary Extracellular matrix is a three-dimensional network of macromolecules that
provide structural and biochemical support to surrounding cells. Extracellular matrix plays a …

Cells in multicellular organisms employ a variety of mechanisms to coordinate their
individual functions with the needs to the whole. Over the past two decades, the extracellular …

The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

The microenvironment plays a central role in cancer, and neoplastic cells actively shape it to
their needs by complex arrays of extracellular matrix (ECM) proteins, enzymes, cytokines …