Background and objective: Isolated systolic hypertension (ISH) affects 10–20% of the elderly
population and is strongly related to the risk of cardiovascular events. Elevated systolic BP …

The pharmacological treatment, mainly based on diuretics, of isolated systolic hypertension
(ISH) has recently been shown to reduce the risk of stroke and coronary heart disease in the …

Objective: The purpose of this 8-week, randomised, single-blind, parallel group, multicentre,
comparative study was to evaluate the efficacy, safety and tolerability of the dihydropyridine …

The antihypertensive efficacy and safety of amlodipine (5-10 mg once daily for 10 weeks)
was assessed in elderly patients with primary systolic hypertension (average sitting and …

Isolated systolic hypertension (ISH) is a definite risk factor for cardiovascular complications
(ie, cardiac failure, coronary artery disease, and stroke) independent of diastolic elevation …

Abstract A 90‐day, multicenter, randomized, double‐blind, parallel‐group study was
conducted to compare the efficacy of amlodipine (once a day) with nicardipine (two to three …

This double-blind, multicenter trial compared antihypertensive efficacy, tolerability, and
impact on quality of life of manidipine and amlodipine in patients with mild-to-moderate …

Abstract The Syst-Eur trial investigated whether active treatment starting with the
dihydropyridine calcium channel blocker (CCB) nitrendipine, could reduce the …

Objective The prevalence of isolated systolic hypertension (ISH) is high in the elderly, and
the objective of this study was to compare the antihypertensive efficacy of olmesartan …

The Systolic Hypertension in Europe (Syst-Eur) study investigated whether antihypertensive
treatment could decrease the risk of cardiovascular complications in elderly patients with …