Tumors without p53 mutation are often resistant to p53 gene therapy. We examined the
mechanism using p53-resistant A549 cells and p53-sensitive H1299 cells. We found that …

Tumor suppressor proteins must be exquisitely regulated since they can induce cell death
while preventing cancer. For example, the p19 ARF tumor suppressor (p14 ARF in humans) …

The p19 ARF gene product responds to oncogenic stresses by interfering with the inhibitory
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …

We have analyzed the ability of an adenoviral vector encoding the exon 1β region of the p14
ARF tumor suppressor (ARF) to suppress the growth and viability of an array of tumor cell …

The p53 tumour suppressor protein is down-regulated by the action of Mdm2, which targets
p53 for rapid degradation by the ubiquitin-proteasome pathway. The p14 ARF protein is also …

The tumor suppressor p19 ARF inhibits Mdm2, which restricts the activity of p53.
Complicated feedback and control mechanisms regulate ARF, Mdm2, and p53 interactions …

Abstract P14/p19 ARF (ARF) plays a major role in the activation of p53 by oncogenic
signals. The biochemical basis of this has not been fully elucidated. We report here that …

p19ARF is a potent tumor suppressor. By inactivating Mdm2, p19ARF upregulates p53
activities to induce cell cycle arrest and sensitize cells to apoptosis in the presence of …

p14 ARF, a product of the INK4A/ARF locus, induces p53 upregulation by neutralizing the
effects of MDM2, a transcriptional target of p53 that antagonizes its function. Here we report …

The MDM2 protein targets the p53 tumor suppressor for ubiquitin-dependent degradation
[1], and can function both as an E3 ubiquitin ligase [2] and as a regulator of the subcellular …