Computational modeling of the obstructive lung diseases asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway
obstruction and airflow limitation and pose a huge burden to society. These obstructive lung …
obstruction and airflow limitation and pose a huge burden to society. These obstructive lung …
Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM)
The respiratory system comprises several scales of biological complexity: the genes, cells
and tissues that work in concert to generate resultant function. Malfunctions of the structure …
and tissues that work in concert to generate resultant function. Malfunctions of the structure …
Relationship between structural changes and hyperpolarized gas magnetic resonance imaging in chronic obstructive pulmonary disease using computational …
M Plotkowiak, K Burrowes, J Wolber… - … of the Royal …, 2009 - royalsocietypublishing.org
Both the development of accurate models of lung function and their quantitative validation
can be significantly enhanced by the use of functional imaging techniques. The advent of …
can be significantly enhanced by the use of functional imaging techniques. The advent of …
Computational lung modelling in respiratory medicine
Computational modelling of the lungs is an active field of study that integrates computational
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …
advances with lung biophysics, biomechanics, physiology and medical imaging to promote …
Pulmonary functional MRI: Detecting the structure–function pathologies that drive asthma symptoms and quality of life
HK Kooner, MJ McIntosh, V Desaigoudar… - …, 2022 - Wiley Online Library
Pulmonary functional MRI (PfMRI) using inhaled hyperpolarized, radiation‐free gases (such
as 3He and 129Xe) provides a way to directly visualize inhaled gas distribution and …
as 3He and 129Xe) provides a way to directly visualize inhaled gas distribution and …
Capturing complexity in pulmonary system modelling
Respiratory disease is a significant problem worldwide, and it is a problem with increasing
prevalence. Pathology in the upper airways and lung is very difficult to diagnose and treat …
prevalence. Pathology in the upper airways and lung is very difficult to diagnose and treat …
An integrative systems biology approach to understanding pulmonary diseases
Chronic inflammatory pulmonary diseases such as COPD and asthma are highly prevalent
and associated with a major health burden worldwide. Despite a wealth of biologic and …
and associated with a major health burden worldwide. Despite a wealth of biologic and …
Probing airway conditions governing ventilation defects in asthma via hyperpolarized MRI image functional modeling
L Campana, J Kenyon… - Journal of Applied …, 2009 - journals.physiology.org
Image functional modeling (IFM) has been introduced as a method to simultaneously
synthesize imaging and mechanical data with computational models to determine the …
synthesize imaging and mechanical data with computational models to determine the …
Models of chronic obstructive pulmonary disease
DA Groneberg, KF Chung - Respiratory research, 2004 - Springer
Chronic obstructive pulmonary disease (COPD) is a major global health problem and is
predicted to become the third most common cause of death by 2020. Apart from the …
predicted to become the third most common cause of death by 2020. Apart from the …
Coupled immunological and biomechanical model of emphysema progression
Chronic Obstructive Pulmonary Disease (COPD) is a disabling respiratory pathology, with a
high prevalence and a significant economic and social cost. It is characterized by different …
high prevalence and a significant economic and social cost. It is characterized by different …