In the brain, neurons and glial cells are equipped with a number of acid–base‐coupled ion
and metabolite transporters, which affect intra‐and extracellular pH. The pH changes can be …

Transport of acid–base equivalents across the cell membrane of neurons and glial cells also
results in pH changes in the extracellular spaces. Cytosolic and extracellular buffer capacity …

Intracellular pH (pH i) regulation in the brain is important in both physiological and
physiopathological conditions because changes in pH i generally result in altered neuronal …

Chesler, Mitchell. Regulation and Modulation of pH in the Brain. Physiol Rev 83: 1183-1221,
2003; 10.1152/physrev. 00010.2003.—The regulation of pH is a vital homeostatic function …

Publisher Summary Evaluating how a cell responds to acid or alkali loads is a powerful
technique for elucidating the mechanisms, kinetics, and regulation of acid–base transporters …

The regulation of H+ in nervous systems is a function of several processes, including H+
buffering, intracellular H+ sequestering, C02 diffusion, carbonic anhydrase activity and …

In nerve and glial cells and in the extracellular spaces of nervous systems pH changes can
be evoked by neuronal activity, by neurotransmitters, by active cellular pH regulation, by …

H+ ions are remarkably efficient modulators of neuronal excitability. This renders brain
functions highly sensitive to small changes in pH which are generated “extrinsically” via …

Maintenance of a stable intracellular pH is central to cell metabolic processes and therefore
for life itself. Regulation of intracellular [Hþ] involves active transport processes, modulation …

Publisher Summary This chapter focuses on the mechanisms, by which non-neuronal cells,
such as Glia, regulate both pH i and pH ECF. It examines some of the basic principles of …