Although rare, retinoblastoma has been at the fore-fortunate; while in the developed world
eye preser-front of cancer research and treatment for the last tion has become a priority …

With an average incidence of 1 in every 18,000 live births, retinoblastoma is a rare type of
intraocular tumour found to affect patients during their early childhood. It is curable if …

Purpose To review the progress made in understanding the genetic basis, molecular
pathology, and treatment of retinoblastoma since the previous Jackson lecture on the topic …

Progressive advances in the understanding of retinoblastoma pathogenesis continue to lead
treatment strategies. Improvements in the diagnosis and management of retinoblastoma are …

Retinoblastoma (OMIM 180200) is the most common ocular tumor of childhood, occurring in
1 in 18,000 live births. In 1809 the disease was first recognized and described with careful …

Retinoblastoma is a rare type of cancer of the eye, often developing in early childhood, that
affects the retina, the light sensitive tissue at the back of the eye that detects light and colour …

After completion of this article, the reader will be able to 1) state the therapeutic interventions
that are currently used to treat intraocular retinoblastoma, and to outline the mechanism of …

Retinoblastoma (Rb), the most frequent malignant intraocular tumor in childhood, is caused
by mutations in the retinoblastoma gene (RB1) situated on chromosome 13q14. 2. The …

Retinoblastoma represents the prototypic model for inherited cancers. The RB1 gene was
the first tumor suppressor gene to be identified. It represents the most frequent primary eye …

Retinoblastoma is the commonest primary ocular malignancy of childhood. There are two
forms—heritable and non heritable. Heritable retinoblastoma is a cancer susceptibility …