Foxp3 expression in human cancer cells

V Karanikas, M Speletas, M Zamanakou… - Journal of translational …, 2008 - Springer
Objective Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the
thymically derived naturally occurring regulatory T cells (Tregs). Limited evidence indicates …

Foxp3 expression in macrophages associated with RENCA tumors in mice

C Devaud, CSM Yong, LB John, JA Westwood… - PloS one, 2014 - journals.plos.org
The transcription factor Foxp3 represents the most specific functional marker of CD4+
regulatory T cells (TRegs). However, previous reports have described Foxp3 expression in …

FoxO3 suppresses Myc-driven lymphomagenesis

CJ Vandenberg, N Motoyama, S Cory - Cell death & disease, 2016 - nature.com
This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO)
transcription factor, can promote lymphomagenesis. Using two different mouse models, we …

Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

JH Kim, J Hwang, JH Jung, HJ Lee, DY Lee, SH Kim - Molecular cancer, 2019 - Springer
Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2,
FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and …

Prognostic value of decreased FOXP1 protein expression in various tumors: a systematic review and meta-analysis

J Xiao, B He, Y Zou, X Chen, X Lu, M Xie, W Li, S He… - Scientific reports, 2016 - nature.com
The prognostic value of forkhead box protein P1 (FOXP1) protein expression in tumors
remains controversial. Therefore, we conducted a systematic review and meta-analysis …

Splice variants of human FOXP3 are functional inhibitors of human CD4+ T‐cell activation

EL Smith, HM Finney, AM Nesbitt, F Ramsdell… - …, 2006 - Wiley Online Library
FOXP3 has been identified as a key regulator of immune homeostasis. Mutations within the
FOXP3 gene result in dysregulated CD4+ T‐cell function and elevated cytokine production …

[HTML][HTML] The dual role of the X-linked FoxP3 gene in human cancers

M Redpath, B Xu, LC van Kempen, A Spatz - Molecular oncology, 2011 - Elsevier
The FoxP3 (forkhead box P3) gene is an X-linked gene that is submitted to inactivation. It is
an essential transcription factor in CD4+ CD25+ FoxP3 regulatory T cells which are …

Neglected, yet significant role of FOXP1 in T-cell quiescence, differentiation and exhaustion

Y Kaminskiy, V Kuznetsova, A Kudriaeva… - Frontiers in …, 2022 - frontiersin.org
FOXP1 is ubiquitously expressed in the human body and is implicated in both physiological
and pathological processes including cancer. However, despite its importance the role of …

Foxp3 expression in T regulatory cells and other cell lineages

C Devaud, PK Darcy, MH Kershaw - Cancer Immunology, Immunotherapy, 2014 - Springer
Abstract Forkhead box P3 (Foxp3) is an important transcription factor that belongs to the
forkhead/winged-helix family of transcriptional regulators. Foxp3 has been extensively …

Targeting FoxM1 transcription factor in T-cell acute lymphoblastic leukemia cell line

Ö Tüfekçi, MK Yandım, H Ören, G İrken, Y Baran - Leukemia research, 2015 - Elsevier
The Forkhead box protein M1 (FoxM1) is an important transcription factor having significant
roles in various cellular events. FoxM1 overexpression has been reported to be related with …