Objectives Dim light at night contributes to neurodegenerative diseases by causing
neuroinflammation. In the central nervous system, the activation of microglia is a significant …

Light pollution is one of the most serious public problems, especially the night light.
However, the effect of dim blue light at night (dLAN-BL) on cognitive function is unclear. In …

Sleep deprivation (SD) is commonplace in today's fast-paced society. SD is a severe public
health problem globally since it may cause cognitive decline and even neurodegenerative …

Melatonin, a naturally occurring neurohormone in the pineal gland, has been shown to exert
antioxidant and anti-inflammatory effects. This study examined the effects of melatonin on …

Chronic social isolation stress (SIS) could impair learning and memory-related behaviors.
Herein, we investigated the efficacy of Melatonin in treatment of memory despair and also its …

Background Depression is a leading cause of disability worldwide and is a major contributor
to the overall global burden of disease, but its etiology is poorly understood. It has been …

Ischemic stroke is a leading cause of mortality and morbidity worldwide, with
neuroinflammation playing a key role in its pathophysiology. Microglia, the primary immune …

Objective To assess the possible neuroprotective effects of melatonin against brain white
matter damage via the Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling …

Seasonal changes in peripheral inflammation are well documented in both humans and
animal models, but seasonal changes in neuroinflammation, especially the impact of …

Melatonin has been shown to down-regulate inflammatory responses and provide
neuroprotection. However, the mechanisms underlying the anti-inflammatory properties of …