Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages

S Ran, J Huang, B Liu, S Gu, W Jiang, J Liang - Microbial Pathogenesis, 2021 - Elsevier
Objectives Enterococcus faecalis is the bacterial species closely related to persistent
infection in root canals. Interleukin-1 beta (IL-1β) is the most commonly detected …

Enterococcus faecalis lipoteichoic acid–induced NLRP3 inflammasome via the activation of the nuclear factor kappa B pathway

L Wang, H Jin, D Ye, J Wang, X Ao, M Dong… - Journal of endodontics, 2016 - Elsevier
Introduction We wished to examine the effects of the nucleotide-binding oligomerization
domain-like receptor protein 3 (NLRP3) inflammasome on periapical periodontitis induced …

[HTML][HTML] Porphyromonas gingivalis-induced NLRP3 inflammasome activation and its downstream interleukin-1β release depend on caspase-4

PH Ding, MX Yang, NN Wang, LJ Jin, Y Dong… - Frontiers in …, 2020 - frontiersin.org
Background: Oral commensals contribute to microbe-host symbiosis in periodontal
homeostasis, and Porphyromonas gingivalis (P. gingivalis) as the keystone pathogen …

Enterococcus faecalis activates caspase-1 leading to increased interleukin-1 beta secretion in macrophages

HH Yang, HK Jun, YJ Jung, BK Choi - Journal of endodontics, 2014 - Elsevier
Introduction Recent studies of inflammasome activation have focused on the pathogenesis
of diverse inflammatory and autoimmune diseases. Inflammasome activation results in …

Regulation of the NLRP3 inflammasome in Porphyromonas gingivalis-accelerated periodontal disease

Y Yamaguchi, T Kurita-Ochiai, R Kobayashi… - Inflammation …, 2017 - Springer
Objective Porphyromonas gingivalis is involved in the pathogenesis of chronic inflammatory
periodontal disease. Recent studies have suggested that the NLRP3 inflammasome plays …

Expression and regulation of the NALP3 inflammasome complex in periodontal diseases

N Bostanci, G Emingil, B Saygan… - Clinical & …, 2009 - academic.oup.com
Periodontitis is an infectious process characterized by inflammation affecting the supporting
structures of the teeth. Porphyromonas gingivalis is a major oral bacterial species implicated …

NLRP6‐caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation

XX Tian, R Li, C Liu, F Liu, LJ Yang… - International …, 2021 - Wiley Online Library
Aim To explore the presence and function of NLRP6‐caspase 4 inflammasome in human
pulp tissue and human dental pulp cells (HDPCs). Methodology Pulp tissue was collected …

Porphyromonas gingivalis triggers NLRP3‐mediated inflammasome activation in macrophages in a bacterial gingipains‐independent manner

T Okano, H Ashida, S Suzuki, M Shoji… - European journal of …, 2018 - Wiley Online Library
Porphyromonas gingivalis is a Gram‐negative anaerobic bacterium that has been
considered to be one of the bacteria associated with progression of human periodontitis …

The activation of pyrin domain-containing-3 inflammasome depends on lipopolysaccharide from Porphyromonas gingivalis and extracellular adenosine triphosphate …

W Guo, P Wang, Z Liu, P Yang, P Ye - BMC Oral Health, 2015 - Springer
Background Gingival epithelial cells are the major population of the gingival tissue, acting as
the front-line defense against microbial intrusion and regulating the homeostasis of the …

Enterococcus faecalis induces apoptosis and pyroptosis of human osteoblastic MG63 cells via the NLRP3 inflammasome

S Ran, M Chu, S Gu, J Wang… - International Endodontic …, 2019 - Wiley Online Library
Aim To investigate the ability of E. faecalis to cause apoptosis and pyroptosis of human
osteoblastic MG 63 cells and whether the inflammasome is involved in this process …