Objective The serrated neoplasia pathway accounts for up to 30% of all sporadic colorectal
cancers (CRCs). Sessile serrated adenomas/polyps (SSA/Ps) with cytological dysplasia …

We describe a series of colorectal polyps characterized by mixed adenomatous and
serrated features, herein referred to as superficially serrated adenomas. Twenty superficially …

Objective To provide an overview of the pathology and molecular pathogenesis of traditional
serrated adenomas (TSA). Design Describe the morphology and molecules that play a role …

In the past two decades, besides conventional adenoma pathway, a subset of colonic
lesions, including hyperplastic polyps, sessile serrated adenoma/polyps, and traditional …

The morphologic distinction between various serrated polyps of the colorectum may be
challenging. The distinction between sessile serrated adenoma (SSA) and traditional …

OBJECTIVES: Sessile serrated adenomas (SSAs) are known to be precursors of sporadic
colorectal cancers (CRCs) with microsatellite instability (MSI), and to be tightly associated …

Colorectal cancer (CRC) is considered a heterogeneous disease, both regarding
pathogenesis and clinical behaviour. Four decades ago, the adenoma–carcinoma pathway …

Serrated lesions are histologically heterogeneous, and detection can be challenging as
these lesions have subtle features that may be missed by endoscopy. Furthermore, while …

The presence or absence of MLH1 methylation may critically affect the heterogeneity of
colorectal carcinoma (CRC) with the CpG island methylator phenotype (CIMP). Here, we …

The serrated neoplastic pathway accounts for approximately 30% of colorectal cancers.
Characterized by mutations in the oncogene BRAF, DNA promoter hypermethylation, and …