Cancer risk assessment methods currently assume that children and adults are equally
susceptible to exposure to chemicals. We reviewed available scientific literature to …

For cancer risk assessment purposes, it is necessary to consider how to incorporate
sensitive subpopulations into the process to ensure that they are appropriately protected …

In revising cancer risk assessment guidelines, the US Environmental Protection Agency
(EPA) analyzed animal cancer bioassay data over different periods of life. In this article, we …

For the vast majority of chemicals that have cancer potency estimates on IRIS, the
underlying database is deficient with respect to early‐life exposures. This data gap has …

The WHO Task Force for the Protection of Children's Environmental Health declared in its
Bangkok statement that “children are not little adults.” 1 The premise behind this principle is …

We considered whether there are discrete windows of vulnerability in the development of
cancer and which time periods may be of the greatest importance. Cancer was considered …

In humans, cancer may be caused by genetics and environmental exposures; however, in
the majority of instances the identification of the critical time window of exposure is …

On 15-16 September 1997, the US Environmental Protection Agency sponsored the
Conference on Preventable Causes of Cancer in Children. The conference was convened to …

In an earlier report we developed a quantitative likelihood-based analysis of the differences
in sensitivity of rodents to mutagenic carcinogens across three life stages (fetal, birth to …

PURPOSE: Many chemical carcinogens are in food, water, air, household products, and
personal care products. Although genetic susceptibility is an important factor in how an …