The maintenance of normal cell function and tissue homeostasis is dependent on the
precise regulation of multiple signaling pathways that control cellular decisions to either …

The life history of cancer cells encompasses a series of genetic missteps in which normal
cells are progressively transformed into tumor cells that invade surrounding tissues and …

Recent discoveries in diverse fields of biomedical research have merged to reveal the
molecular basis of cell cycle control and a critical role of subverting this homeostatic …

The retinoblastoma tumor suppressor protein (Rb) plays a vital role in regulating mammalian
cell cycle progression and inactivation of Rb is necessary for entry into S phase. Rb is …

Dr Ante Lundberg is a post-doctoral fellow at the Whitehead Institute for Biomedical
Research, and a Research Fellow at Harvard Medical School. He received his B. Sc. degree …

The control of cellular proliferation is key in the proper development of a complex organism,
the maintenance of tissue homeostasis, and the ability to respond to various hormonal and …

The retinoblastoma gene, Rb, was originally identified as the tumor suppressor gene
mutated in a rare childhood cancer called retinoblastoma (reviewed in [1]). Subsequent …

c-Myc is frequently deregulated in human cancers. Although deregulated c-Myc leads to
tumor growth, it also triggers apoptosis in partnership with tumor suppressors such as ARF …

Abstract The Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-
signal-regulated kinase (ERK) cascade couples signals from cell surface receptors to …

The retinoblastoma (RB) tumor suppressor belongs to a cellular pathway that plays a crucial
role in restricting the G1-S transition of the cell cycle in response to a large number of …