Cholesteryl ester transfer protein inhibitors: trials and tribulations
JH McLain, AJ Alsterda… - Journal of cardiovascular …, 2017 - journals.sagepub.com
The cholesteryl ester transfer protein (CETP) is a plasma protein that plays an important role
in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely …
in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely …
Future of cholesteryl ester transfer protein inhibitors
DJ Rader, EM deGoma - Annual review of medicine, 2014 - annualreviews.org
The cholesteryl ester transfer protein (CETP) plays an integral role in the metabolism of
plasma lipoproteins. Despite two failures, CETP inhibitors are still in clinical development …
plasma lipoproteins. Despite two failures, CETP inhibitors are still in clinical development …
Refocusing on use of cholesteryl ester transfer protein inhibitors
JJP Kastelein - The American journal of cardiology, 2007 - Elsevier
Cholesteryl ester transfer protein (CETP) plays an important role in cholesterol metabolism
because it is responsible for the transfer of cholesteryl esters from high-density lipoprotein …
because it is responsible for the transfer of cholesteryl esters from high-density lipoprotein …
Cholesteryl ester transfer protein inhibition to reduce cardiovascular risk: where are we now?
Elevated low-density lipoprotein-cholesterol (LDL-C) and reduced high-density lipoprotein-
cholesterol (HDL-C) are major risk factors for the development of cardiovascular disease …
cholesterol (HDL-C) are major risk factors for the development of cardiovascular disease …
Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events: JACC Review Topic of the Week
Cholesteryl ester transfer protein (CETP) facilitates exchange of triglycerides and cholesteryl
ester between high-density lipoprotein (HDL) and apolipoprotein B100–containing …
ester between high-density lipoprotein (HDL) and apolipoprotein B100–containing …
Future of cholesteryl ester transfer protein (CETP) inhibitors: a pharmacological perspective
AH Mohammadpour, F Akhlaghi - Clinical pharmacokinetics, 2013 - Springer
In almost 30 years since the introduction of HMG-CoA reductase inhibitors (statins), no other
class of lipid modulators has entered the market. Elevation of high-density lipoprotein …
class of lipid modulators has entered the market. Elevation of high-density lipoprotein …
Anacetrapib, a cholesteryl ester transfer protein inhibitor
AJ Hooper, JR Burnett - Expert Opinion on Investigational Drugs, 2012 - Taylor & Francis
Introduction: Inhibition of cholesteryl ester transfer protein (CETP) has the ability to increase
high-density lipoprotein (HDL)-cholesterol levels and potentially reduce cardiovascular risk …
high-density lipoprotein (HDL)-cholesterol levels and potentially reduce cardiovascular risk …
Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease
PJ Barter, JJP Kastelein - Journal of the American College of Cardiology, 2006 - jacc.org
Epidemiologic studies have shown that the concentration of high-density lipoprotein
cholesterol (HDL-C) is a strong, independent, inverse predictor of coronary heart disease …
cholesterol (HDL-C) is a strong, independent, inverse predictor of coronary heart disease …
Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib
AS Goldberg, RA Hegele - Drug design, development and therapy, 2012 - Taylor & Francis
Among the noteworthy recent stories in the management and prevention of atherosclerotic
cardiovascular disease (CVD) is the saga of the development of pharmacological inhibitors …
cardiovascular disease (CVD) is the saga of the development of pharmacological inhibitors …
The role of CETP inhibition in dyslipidemia
K El Harchaoui, WA van der Steeg, ESG Stroes… - Current atherosclerosis …, 2007 - Springer
Cholesteryl ester transfer protein (CETP) inhibitors are currently being investigated because
of their ability to increase high-density lipoprotein cholesterol levels. In various metabolic …
of their ability to increase high-density lipoprotein cholesterol levels. In various metabolic …