Current progress for the use of miRNAs in glioblastoma treatment

A Tivnan, KL McDonald - Molecular neurobiology, 2013 - Springer
Glioblastoma (GBM) is a highly aggressive brain cancer with the worst prognosis of any
central nervous system disease despite intensive multimodal therapy. Inevitably …

Targeting microRNAs in prevention and treatment of neurodegenerative disorders

S Gupta, S Verma, S Mantri… - Drug development …, 2015 - Wiley Online Library
ABSTRACT Preclinical Research microRNAs (miRNAs) are small noncoding RNAs
(ncRNAs) that are key regulators of gene expression. They act on wide range of targets by …

MicroRNAs as newer therapeutic targets: A big hope from a tiny player

HS Ghelani, MA Rachchh… - … of Pharmacology and …, 2012 - journals.sagepub.com
MicroRNAs (miRNAs) are a novel group of universally present small noncoding
endogenous RNAs that regulate gene expression and protein coding by base pairing with …

MicroRNAs in neurodegenerative diseases and their therapeutic potential

E Junn, MM Mouradian - Pharmacology & therapeutics, 2012 - Elsevier
MicroRNAs (miRNAs) are abundant, endogenous, short, noncoding RNAs that act as
important post-transcriptional regulators of gene expression by base-pairing with their target …

Neurodegenerative disorders treatment: the MicroRNA role

B Ridolfi, H Abdel-Haq - Current gene therapy, 2017 - ingentaconnect.com
Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, Huntington's disease and prion disease are not timely and …

[HTML][HTML] microRNAs involved in Parkinson's disease: A systematic review

FC Da Silva, RR Iop, GG Vietta… - Molecular …, 2016 - spandidos-publications.com
The aim of the present study was to determine the expression of blood microRNAs (miRNAs)
involved in PD in humans. For this purpose the following electronic databases were …

Alterations of miRNAs reveal a dysregulated molecular regulatory network in Parkinson's disease striatum

VD Nair, Y Ge - Neuroscience Letters, 2016 - Elsevier
Molecular adaptations in the striatum mediated by dopamine (DA) denervation and/or
levodopa (L-dopa) treatments have been implicated in the motor deficits found in …

Species-specific miRNAs in human brain development and disease

K Prodromidou, R Matsas - Frontiers in cellular neuroscience, 2019 - frontiersin.org
Identification of the unique features of human brain development and function can be critical
towards the elucidation of intricate processes such as higher cognitive functions and human …

Meta‐analyses identify differentially expressed microRNAs in Parkinson's disease

J Schulz, P Takousis, I Wohlers, IOG Itua… - Annals of …, 2019 - Wiley Online Library
Objective MicroRNA (miRNA)‐mediated (dys) regulation of gene expression has been
implicated in Parkinson's disease (PD), although results of miRNA expression studies …

Tiny but mighty: promising roles of microRNAs in the diagnosis and treatment of Parkinson's disease

Y Wang, Z Yang, W Le - Neuroscience Bulletin, 2017 - Springer
Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder after Alzheimer's disease. To date, the clinical diagnosis of PD is primarily based on …