Targeting microRNAs in neurons: tools and perspectives
In the past few years, the understanding of microRNA (miRNA) biogenesis, the molecular
mechanisms by which miRNAs regulate gene expression, and the functional roles of …
mechanisms by which miRNAs regulate gene expression, and the functional roles of …
Understanding the involvement of microRNAs in mitochondrial dysfunction and their role as potential biomarkers and therapeutic targets in Parkinson's disease
KP Tryphena, U Anuradha, R Kumar… - Journal of …, 2023 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
the elderly worldwide and causing significant movement impairments. The goal of PD …
the elderly worldwide and causing significant movement impairments. The goal of PD …
[HTML][HTML] Regulatory miRNA–mRNA networks in Parkinson's disease
BL Santos-Lobato, AF Vidal, Â Ribeiro-dos-Santos - Cells, 2021 - mdpi.com
Parkinson's disease (PD) is the second-most common neurodegenerative disease, and its
pathophysiology is associated with alpha-synuclein accumulation, oxidative stress …
pathophysiology is associated with alpha-synuclein accumulation, oxidative stress …
MicroRNAs: novel therapeutic targets in neurodegenerative diseases
The prevalence of neurodegenerative disorders is rising steadily as human life expectancy
increases. However, limited knowledge of the molecular basis of disease pathogenesis is a …
increases. However, limited knowledge of the molecular basis of disease pathogenesis is a …
MicroRNAs: possible role in pathogenesis of Parkinson's disease
EV Filatova, AK Alieva, MI Shadrina… - Biochemistry (Moscow …, 2012 - Springer
Parkinson's disease is one of the most common human neurodegenerative disorders
caused by the loss of dopaminergic neurons from the substantia nigra pars compacta of …
caused by the loss of dopaminergic neurons from the substantia nigra pars compacta of …
Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that
manifest various motor and nonmotor symptoms. Although currently available therapies can …
manifest various motor and nonmotor symptoms. Although currently available therapies can …
[HTML][HTML] Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases
J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …
[HTML][HTML] Exploring microRNA biomarkers for Parkinson's disease from mRNA expression profiles
YH Taguchi, H Wang - Cells, 2018 - mdpi.com
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease
characterized by both motor and nonmotor features. The diagnose of PD is based on a …
characterized by both motor and nonmotor features. The diagnose of PD is based on a …
[HTML][HTML] Aberrant expression of circulating MicroRNA leads to the dysregulation of alpha-synuclein and other pathogenic genes in Parkinson's disease
M Cai, S Chai, T Xiong, J Wei, W Mao, Y Zhu… - Frontiers in Cell and …, 2021 - frontiersin.org
A group of circulating microRNAs (miRNAs) have been implicated in the pathogenesis of
Parkinson's disease. However, a comprehensive study of the interactions between …
Parkinson's disease. However, a comprehensive study of the interactions between …
miRNAs as biomarkers of neurodegenerative disorders
V Viswambharan, I Thanseem, MM Vasu… - Biomarkers in …, 2017 - Taylor & Francis
Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons,
ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing …
ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing …