Targeting microRNAs in neurons: tools and perspectives

F Ruberti, C Barbato, C Cogoni - Experimental neurology, 2012 - Elsevier
In the past few years, the understanding of microRNA (miRNA) biogenesis, the molecular
mechanisms by which miRNAs regulate gene expression, and the functional roles of …

Understanding the involvement of microRNAs in mitochondrial dysfunction and their role as potential biomarkers and therapeutic targets in Parkinson's disease

KP Tryphena, U Anuradha, R Kumar… - Journal of …, 2023 - content.iospress.com
Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
the elderly worldwide and causing significant movement impairments. The goal of PD …

[HTML][HTML] Regulatory miRNA–mRNA networks in Parkinson's disease

BL Santos-Lobato, AF Vidal, Â Ribeiro-dos-Santos - Cells, 2021 - mdpi.com
Parkinson's disease (PD) is the second-most common neurodegenerative disease, and its
pathophysiology is associated with alpha-synuclein accumulation, oxidative stress …

MicroRNAs: novel therapeutic targets in neurodegenerative diseases

R Roshan, T Ghosh, V Scaria, B Pillai - Drug discovery today, 2009 - Elsevier
The prevalence of neurodegenerative disorders is rising steadily as human life expectancy
increases. However, limited knowledge of the molecular basis of disease pathogenesis is a …

MicroRNAs: possible role in pathogenesis of Parkinson's disease

EV Filatova, AK Alieva, MI Shadrina… - Biochemistry (Moscow …, 2012 - Springer
Parkinson's disease is one of the most common human neurodegenerative disorders
caused by the loss of dopaminergic neurons from the substantia nigra pars compacta of …

Progress in the molecular pathogenesis and nucleic acid therapeutics for Parkinson's disease in the precision medicine era

D Li, FL Mastaglia, S Fletcher… - Medicinal Research …, 2020 - Wiley Online Library
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that
manifest various motor and nonmotor symptoms. Although currently available therapies can …

[HTML][HTML] Molecular biomarkers and their implications for the early diagnosis of selected neurodegenerative diseases

J Doroszkiewicz, M Groblewska, B Mroczko - International Journal of …, 2022 - mdpi.com
The degeneration and dysfunction of neurons are key features of neurodegenerative
diseases (NDs). Currently, one of the main challenges facing researchers and clinicians is …

[HTML][HTML] Exploring microRNA biomarkers for Parkinson's disease from mRNA expression profiles

YH Taguchi, H Wang - Cells, 2018 - mdpi.com
Parkinson's disease (PD) is a chronic, progressive neurodegenerative disease
characterized by both motor and nonmotor features. The diagnose of PD is based on a …

[HTML][HTML] Aberrant expression of circulating MicroRNA leads to the dysregulation of alpha-synuclein and other pathogenic genes in Parkinson's disease

M Cai, S Chai, T Xiong, J Wei, W Mao, Y Zhu… - Frontiers in Cell and …, 2021 - frontiersin.org
A group of circulating microRNAs (miRNAs) have been implicated in the pathogenesis of
Parkinson's disease. However, a comprehensive study of the interactions between …

miRNAs as biomarkers of neurodegenerative disorders

V Viswambharan, I Thanseem, MM Vasu… - Biomarkers in …, 2017 - Taylor & Francis
Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons,
ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing …