The loss of neurons due to injury and disease results in a wide spectrum of highly disabling
neurological and neurodegenerative conditions, given the apparent limited capacity of …

Parkinson's disease is the second most common neurodegenerative disease commonly
affecting the older population. Loss of dopaminergic neurons in the substantia nigra of brain …

ABSTRACT Parkinson's disease (PD), a neurodegenerative disorder characterized by the
selective degeneration of the nigrostriatal dopaminergic pathway, is a major socio-economic …

Alzheimer's disease (AD) is the most common cause of dementia. Currently, a clinical
diagnosis of AD is based on evidence of both cognitive and functional decline. Progression …

Despite the identification of several dozens of common genetic variants associated with
Alzheimer's disease (AD) and Parkinson's disease (PD), most of the genetic risk remains …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects upper and
lower motor neurons. As there is no effective treatment for ALS, it is particularly important to …

MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets
and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be …

Chronic demyelination is a hallmark of neurological disorders such as multiple sclerosis
(MS) and several leukodystrophies. In the central nervous system (CNS), remyelination is a …

microRNAs (miRNAs) act as post-transcriptional regulators of gene expression in diverse
cellular and developmental processes. Many miRNAs are expressed specifically in the …

MicroRNAs (miRNAs) are a class of small, well-conserved noncoding RNAs that regulate
gene expression post-transcriptionally. They have been demonstrated to regulate a lot of …