Titanium peroxide nanoparticles enhanced cytotoxic effects of X-ray irradiation against pancreatic cancer model through reactive oxygen species generation in vitro …

M Nakayama, R Sasaki, C Ogino, T Tanaka, K Morita… - Radiation …, 2016 - Springer
Background Biological applications of nanoparticles are rapidly increasing, which
introduces new possibilities to improve the efficacy of radiotherapy. Here, we synthesized …

Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells

M Salah, H Akasaka, Y Shimizu, K Morita… - Journal of Experimental …, 2022 - Springer
Background Despite recent advances in radiotherapy, radioresistance in patients with
pancreatic cancer remains a crucial dilemma for clinical treatment. Cancer stem cells …

Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

MS Wason, J Colon, S Das, S Seal, J Turkson… - … , Biology and Medicine, 2013 - Elsevier
Side effect of radiation therapy (RT) remains the most challenging issue for pancreatic
cancer treatment. In this report we determined whether and how cerium oxide nanoparticles …

Characterization of titanium dioxide nanoparticles modified with polyacrylic acid and H2O2 for use as a novel radiosensitizer

K Morita, S Miyazaki, C Numako, S Ikeno… - Free Radical …, 2016 - Taylor & Francis
An induction of polyacrylic acid-modified titanium dioxide with hydrogen peroxide
nanoparticles (PAA-TiO2/H2O2 NPs) to a tumor exerted a therapeutic enhancement of X-ray …

Cerium oxide nanoparticles sensitize pancreatic cancer to radiation therapy through oxidative activation of the JNK apoptotic pathway

MS Wason, H Lu, L Yu, SK Lahiri, D Mukherjee… - Cancers, 2018 - mdpi.com
Side effects of radiation therapy (RT) remain the most challenging issue for pancreatic
cancer treatment. Cerium oxide nanoparticles (CONPs) are currently being tested in pre …

Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells

K Morita, Y Nishimura, S Nakamura, Y Arai… - Colloids and Surfaces B …, 2021 - Elsevier
Polyacrylic acid-modified titanium peroxide nanoparticles (PAA-TiO x NPs) are promising
radiosensitizers that enhance the therapeutic effect of X-ray irradiation after local injection …

Samarium doped titanium dioxide nanoparticles as theranostic agents in radiation therapy

M Nakayama, CL Smith, BN Feltis, TJ Piva… - Physica Medica, 2020 - Elsevier
Abstract Purpose Titanium dioxide nanoparticles (TiO 2 NPs) have been investigated for
their role as radiosensitisers for radiation therapy. The study aims to increase the efficiency …

Nanoparticle augmented radiation treatment decreases cancer cell proliferation

HE Townley, E Rapa, G Wakefield… - … , biology and medicine, 2012 - Elsevier
We report significant and controlled cell death using novel x-ray-activatable titania
nanoparticles (NPs) doped with lanthanides. Preferential incorporation of such materials into …

Calcium peroxide nanoparticles induce endoplasmic reticulum stress for enhanced radiation therapy of osteosarcoma

Z Liu, Z Fu, M Zhao, H Wang, X Ji, J Zhou, W Gu, Y Gu… - Nano Today, 2024 - Elsevier
Radiation therapy (RT) has been widely used in clinics. The expression of various radiation-
resistant proteins limits the curative effect of RT. Endoplasmic reticulum (ER) plays a critical …

Au-Pt nanoparticle formulation as a radiosensitizer for radiotherapy with dual effects

S Yang, G Han, Q Chen, L Yu, P Wang… - International journal …, 2021 - Taylor & Francis
Background Radiotherapy occupies an essential position as one of the most significant
approaches for the clinical treatment of cancer. However, we cannot overcome the …