The antinociceptive, tolerance-developing and anti-withdrawal activities of tizanidine [5-
chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzo-thiadiazole] were investigated by …

The antinociceptive action of tizanidine [5-chloro-(2-imidazolin-2-yl-amino)-2, 1, 3-
benzothiadiazole], a centrally acting muscle relaxant, was evaluated after subcutaneous or …

Abstract Male Sprague Dawley rats were trained in a two‐lever food‐reinforced procedure to
discriminate between the effects of saline and either tizanidine hydrochloride, clonidine …

The effect of drugs that influence the opioidergic and monoaminergic neuronal systems on
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3 …

Abstract Tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiadiazole] is able to
increase the pain threshold in the tail-flick test in mice. The effect of tizanidine was …

The influence of tiagabine at a dose of 3.2 mg/kg (single administration) and at a dose of 1.2
mg/kg (multiple administration ñ 10 days) on the antinociceptive effect of morphine (10 …

Long-term use of morphine can cause neuronal dystrophic changes in specific areas of the
brain. These changes may underlie the mechanism for developing morphine antinociceptive …

The present study investigated the effect of co-administration of ketanserin, a 5-HT2A
receptor antagonist and dizocilpine, a non-competitive NMDA receptor antagonist on the …

Objectives: The aim of this study was to investigate effect of zimelidine (a serotonin reuptake
inhibitor) on morphine-induced tolerance in rats. Materials and Methods: Male Wistar albino …

1Tetrandrine (TET), a non-specific calcium antagonist, inhibited morphine-induced
antinociception in the tail-flick test in mice. This study was undertaken to assess the …