The lncRNA RZE1 Controls Cryptococcal Morphological Transition

N Chacko, Y Zhao, E Yang, L Wang, JJ Cai, X Lin - PLoS genetics, 2015 - journals.plos.org
In the fungal pathogen Cryptococcus neoformans, the switch from yeast to hypha is an
important morphological process preceding the meiotic events during sexual development …

The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

L Wang, B Zhai, X Lin - PLoS pathogens, 2012 - journals.plos.org
Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can
undergo morphotype transition between the yeast and the filamentous form and such …

The Cys2His2 zinc finger protein Zfp1 regulates sexual reproduction and virulence in Cryptococcus neoformans

CL Fan, LT Han, ST Jiang, AN Chang, ZY Zhou… - Fungal genetics and …, 2019 - Elsevier
Cryptococcus neoformans is a ubiquitous yeast pathogen that often infects the human
central nervous system (CNS) to cause meningitis in immunocompromised individuals …

PAS domain protein Pas3 interacts with the chromatin modifier Bre1 in regulating cryptococcal morphogenesis

Y Zhao, S Upadhyay, X Lin - MBio, 2018 - Am Soc Microbiol
Switching between different morphotypes is an adaptive cellular response in many
microbes. In Cryptococcus neoformans, the yeast-to-hypha transition confers resistance to …

Morphology and its underlying genetic regulation impact the interaction between Cryptococcus neoformans and its hosts

J Lin, A Idnurm, X Lin - Medical mycology, 2015 - academic.oup.com
Cryptococcus neoformans is a fungus that causes the majority of fatal cryptococcal
meningitis cases worldwide. This pathogen is capable of assuming different morphotypes …

Morphotype-specific effector functions of Cryptococcus neoformans PUM1

JN Kaur, JC Panepinto - Scientific Reports, 2016 - nature.com
The basidiomycete fungal pathogen Cryptococcus neoformans requires the PUF protein,
Pum1, for hyphal morphogenesis during sexual development. In this study we found that …

Glucosamine stimulates pheromone-independent dimorphic transition in Cryptococcus neoformans by promoting Crz1 nuclear translocation

X Xu, J Lin, Y Zhao, E Kirkman, YS So, YS Bahn… - PLoS …, 2017 - journals.plos.org
Morphotype switch is a cellular response to external and internal cues. The Cryptococcus
neoformans species complex can undergo morphological transitions between the yeast and …

Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants

B Zhai, KL Wozniak, J Masso-Silva, S Upadhyay… - MBio, 2015 - Am Soc Microbiol
Morphological switch is tightly coupled with the pathogenesis of many dimorphic fungal
pathogens. Cryptococcus neoformans, the major causative agent of cryptococcal meningitis …

Transcription factor Znf2 coordinates with the chromatin remodeling SWI/SNF complex to regulate cryptococcal cellular differentiation

J Lin, Y Zhao, AR Ferraro, E Yang, ZA Lewis… - Communications …, 2019 - nature.com
Cellular differentiation is instructed by developmental regulators in coordination with
chromatin remodeling complexes. Much information about their coordination comes from …

Cryptococcus neoformans: sex, morphogenesis, and virulence

Y Zhao, X Lin - Infection, Genetics and Evolution, 2021 - Elsevier
Cryptococcus neoformans is a dimorphic fungus that causes lethal meningoencephalitis
mainly in immunocompromised individuals. Different morphotypes enable this …