Glycation reactions resulting in the generation and accumulation of advanced glycation
endproducts (AGEs) are potential mechanisms by which bone protein may be altered in …

Background: The process of bone remodelling is disturbed in the development of
osteoporosis. Objective: To investigate if proteins in osteoporotic bone are modified by …

Objective Advanced glycation end products (AGEs) have been implicated in the
pathogenesis of bone-destructive disorders. Yet reports on the influence of AGEs on human …

Advanced glycation endproducts (AGEs) are chemical modifications of proteins by
carbohydrates including those metabolic intermediates formed during the Maillard reaction …

Osteoporosis, one of the most prevalent metabolic bone diseases in developed countries, is
a major public health problem through its association with fragility fractures. Several …

Osteoporosis, a multifactorial and progressive skeletal metabolic disease, is characterized
by low‐mass density and structural deterioration of bone micro‐architecture that leads to …

Type I collagen, the major organic component of bone matrix, undergoes a series of post-
translational modifications that occur with aging, such as the non-enzymatic glycation. This …

Advanced glycation end products (AGEs) have been observed to accumulate in bone with
increasing age and may impose effects on bone resorption activities. However, the …

Diabetes patients are at high risk of bone fracture due to accumulation of advanced
glycation end products (AGEs) and low bone turnover. Although AGEs inhibit osteoblast …

An increase in the interaction between advanced glycation end-products (AGEs) and their
receptor RAGE is believed to contribute to the pathogenesis of chronic complications of …