Purpose: For many tumor cells, de novo lipogenesis is a requirement for growth and
survival. A considerable body of work suggests that inhibition of this pathway may be a …

Arachidonic acid metabolism plays an important role in colon carcinogenesis.
Cyclooxygenase-2 (COX-2), which catalyzes the rate-limiting step in the synthesis of …

Fatty acid synthase (FASN) is a key enzyme involved in neoplastic lipogenesis.
Overexpression of FASN is common in many cancers, and accumulating evidence suggests …

Substantial studies on fatty acid synthase (FASN) have focused on its role in regulating lipid
metabolism and researchers have a great interest in treating cancer with dietary …

Tumorigenesis involves metabolic reprogramming and abnormal lipid metabolism, which is
manifested by increased endogenous fat mobilization, hypertriglyceridemia, and increased …

Background & Aims Cumulating evidence underlines the crucial role of aberrant lipogenesis
in human hepatocellular carcinoma (HCC). Here, we investigated the oncogenic potential of …

Most cancer‐related deaths result from the progressive growth of metastases. Patients with
peritoneal metastatic (PM) colorectal cancer have reduced overall survival. Currently, it is …

Fatty acid synthase (FASN), the key metabolic enzyme of de novo lipogenesis, provides
proliferative and metastatic capacity directly to cancer cells have been described. However …

Metabolic reprogramming is a central feature of transformed cells. Cancer metabolism is
now fully back in the focus of cancer research, as the interactions between oncogenic …

AIM: Fatty acid-CoA ligase 4 (FACL4) is an arachidonate-preferring enzyme which has been
shown to be up-regulated in human colon cancer tissues and implicated in the colon …