The hepatocyte growth factor (HGF)/c-Met signaling pathway is involved in the progression
of several cancers and associated with increased tumor invasion and metastatic potential …

Background Enhanced macromolecule biosynthesis is integral to growth and proliferation of
cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer …

In normal tissues, energy-providing lipids come principally from circulating lipids. However,
in growing tumors, energy supply is mainly provided by lipids coming from de novo …

The alterations in carbohydrate metabolism that fuel tumor growth have been extensively
studied. However, other metabolic pathways involved in malignant progression, demand …

Background The lipogenic enzyme fatty acid synthase (FAS) is up-regulated in a wide
variety of cancers, and is considered a potential metabolic oncogene by virtue of its ability to …

A biologically aggressive subset of human breast cancers has been demonstrated to
overexpress fatty acid synthase (FAS), the key enzyme of endogenous FA biosynthesis. This …

Multidrug resistance is a major problem in successful cancer chemotherapy. Various
mechanisms of resistance, such as ABC transporter-mediated drug efflux, have been …

This study aimed to investigate the role of fatty acid synthase (FASN) in the epithelial-
mesenchymal transition (EMT) of breast cancer cells. MCF-7 cells and MCF-7 cells …

Hepatocellular carcinoma (HCC), the most frequent primary tumor of the liver, is an
aggressive cancer type with limited treatment options. Cumulating evidence underlines a …

Purpose: Lipid metabolism reprogramming is a major pathway in tumor evolution. This study
investigated fatty acid synthase (FASN) mRNA expression in anthropometric adipose tissue …