The expression and activity of Fatty Acid Synthase (FASN; the sole enzyme capable of the
reductive de novo synthesis of long-chain fatty acids from acetyl-CoA, malonyl-CoA, and …

Fatty acid synthase (FAS) has been found to be overexpressed in a wide range of epithelial
tumors, including breast cancer. Pharmacologic inhibitors of FAS cause apoptosis of breast …

Purpose Energy balance seems to be important in the pathogenesis of colon cancer. Fatty
acid synthase (FASN) is physiologically regulated by energy balance and is often …

Fatty acid synthase (FASN) is a key enzyme in fat biosynthesis that is over-expressed in
advanced breast cancer stages. Cisplatin (CDDP) is a platinum-based drug used in the …

Fatty acid‐CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified arachidonic
acid (AA) level in cells. It has been shown that FACL4 blocks apoptosis and promotes colon …

Fatty acid synthase (FASN) is the metabolic enzyme responsible for the endogenous
synthesis of the saturated long-chain fatty acid, palmitate. In contrast to most normal cells …

Emerging literature suggests that metabolic pathways play an important role in the
maintenance and progression of human cancers. In particular, recent studies have …

Aberrant fatty acid (FA) metabolism has long been recognized in colorectal cancer (CRC)
cells. Since de novo lipogenesis is required for CRC tumour growth and survival, the …

Cervical cancer (CC) patients with lymph node metastasis (LNM) have a poor prognosis.
Clarification of the detailed mechanisms underlying LNM may provide potential clinical …

Ovarian cancer (OC) is caused by genetic aberrations in networks that control growth and
survival. Importantly, aberrant cancer metabolism interacts with oncogenic signaling …