Safety and outcomes associated with the pharmacological inhibition of the kinin–kallikrein system in severe COVID-19
E Mansour, AC Palma, RG Ulaf, LC Ribeiro… - Viruses, 2021 - mdpi.com
Background: Coronavirus disease 19 (COVID-19) can develop into a severe respiratory
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …
syndrome that results in up to 40% mortality. Acute lung inflammatory edema is a major …
[PDF][PDF] Kinins and cytokines in COVID-19: a comprehensive pathophysiological approach
F van de Veerdonk, MG Netea, M van Deuren… - 2020 - pdfs.semanticscholar.org
Most striking observations in COVID-19 patients are the hints on pulmonary edema (also
seen on CT scans as ground glass opacities), dry cough, fluid restrictions to prevent more …
seen on CT scans as ground glass opacities), dry cough, fluid restrictions to prevent more …
Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial
E Mansour, FF Bueno, JC de Lima-Júnior, A Palma… - Trials, 2021 - Springer
Abstract Background SARS-CoV-2, the virus that causes COVID-19, enters the cells through
a mechanism dependent on its binding to angiotensin-converting enzyme 2 (ACE2), a …
a mechanism dependent on its binding to angiotensin-converting enzyme 2 (ACE2), a …
Dysregulated Bradykinin: Mystery in the Pathogenesis of COVID‐19
The COVID‐19 pandemic is rapidly spreading, and health care systems are being
overwhelmed with the huge number of cases, with a good number of cases requiring …
overwhelmed with the huge number of cases, with a good number of cases requiring …
A lesson from a saboteur: High‐MW kininogen impact in coronavirus‐induced disease 2019
C Colarusso, M Terlizzi, A Pinto… - British Journal of …, 2020 - Wiley Online Library
The newly identified coronavirus SARS‐CoV‐2 that spread from China is causing the
pandemic COVID‐19 with a fatality rate from 5‐15%. It causes fever, cough, myalgia, fatigue …
pandemic COVID‐19 with a fatality rate from 5‐15%. It causes fever, cough, myalgia, fatigue …
Angioedema in COVID-19
AJ Cohen, MF DiFrancesco, SD Solomon… - European Heart …, 2020 - academic.oup.com
A 62-year-old man with a history of hypertension presented with 12 h of lip and facial
swelling. Twelve days prior to presentation, he developed fevers (up to 39 C), chills, fatigue …
swelling. Twelve days prior to presentation, he developed fevers (up to 39 C), chills, fatigue …
What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?
Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease with fast spreading
all over the world caused by the SARS-CoV-2 virus which can culminate in a severe acute …
all over the world caused by the SARS-CoV-2 virus which can culminate in a severe acute …
[HTML][HTML] A hypothesized role for dysregulated bradykinin signaling in COVID‐19 respiratory complications
Abstract As of April 20, 2020, over time, the COVID‐19 pandemic has resulted in 157 970
deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of~ 6.8%. With the …
deaths out of 2 319 066 confirmed cases, at a Case Fatality Rate of~ 6.8%. With the …
Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome
FL van de Veerdonk, MG Netea, M van Deuren… - Elife, 2020 - elifesciences.org
COVID-19 patients can present with pulmonary edema early in disease. We propose that
this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) …
this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) …
The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology
D Sohaei, M Hollenberg, SJ Janket… - Critical Reviews in …, 2023 - Taylor & Francis
Abstract While coronavirus disease 2019 (COVID-19) begins as a respiratory infection, it
progresses as a systemic disease involving multiorgan microthromboses that underly the …
progresses as a systemic disease involving multiorgan microthromboses that underly the …