[HTML][HTML] The role of cGAS-STING in age-related diseases from mechanisms to therapies
With aging, the incidence of age-related diseases increases. Hence, age-related diseases
are inevitable. However, the mechanisms by which aging leads to the onset and progression …
are inevitable. However, the mechanisms by which aging leads to the onset and progression …
cGAS–STING, an important signaling pathway in diseases and their therapy
Since cyclic guanosine monophosphate‐adenosine monophosphate synthase (cGAS)–
stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great …
stimulator of interferon genes (STING) signaling pathway was discovered in 2013, great …
cGAS-STING pathway as a potential trigger of immunosenescence and inflammaging
CRR Schmitz, RM Maurmann, FTCR Guma… - Frontiers in …, 2023 - frontiersin.org
Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …
progressive decline of immune responses (immunosenescence). This apparent paradox can …
The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumors
PH Zeng, WJ Yin - Cell Cycle, 2023 - Taylor & Francis
The cGAS/STING signaling pathway is an important part of the cytoplasmic DNA sensor,
which can trigger a type I interferon response to microbial infection when pathogenic DNA is …
which can trigger a type I interferon response to microbial infection when pathogenic DNA is …
The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
The cGAS–STING pathway: more than fighting against viruses and cancer
T Bao, J Liu, J Leng, L Cai - Cell & Bioscience, 2021 - Springer
In the classic Cyclic guanosine monophosphate–adenosine monophosphate (cGAMP)
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …
synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can …
Cellular functions of cGAS-STING signaling
C Chen, P Xu - Trends in cell biology, 2023 - cell.com
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic,
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
mitochondrial, and microbial double-stranded DNA (dsDNA) to synthesize 2′ 3′-cGAMP …
Significance of the cGAS-STING pathway in health and disease
J Zhou, Z Zhuang, J Li, Z Feng - International Journal of Molecular …, 2023 - mdpi.com
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …
a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic …
Research advances in how the cGAS-STING pathway controls the cellular inflammatory response
D Wan, W Jiang, J Hao - Frontiers in immunology, 2020 - frontiersin.org
Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …
downstream stimulator of interferon genes (STING) acting as essential immune-surveillance …