Nitric oxide in the gastrointestinal tract: opportunities for drug development

JL Wallace - British journal of pharmacology, 2019 - Wiley Online Library
Nitric oxide (NO) plays important roles in gastrointestinal mucosal defence, as well as in the
pathogenesis of several gastrointestinal diseases (eg irritable bowel syndrome and …

Nitric oxide-a mediator of inflammation or mucosal defence

BJR Whittle - European journal of gastroenterology & hepatology, 1997 - journals.lww.com
Nitric oxide (NO) can exert both protective and proinflammatory actions in the
gastrointestinal tract. NO, formed physiologically by constitutive NO synthases, regulates …

The potential role of nitric oxide in chronic inflammatory bowel disorders

Perner - Alimentary pharmacology & therapeutics, 1999 - Wiley Online Library
The aetiology of the chronic inflammatory bowel diseases—ulcerative colitis and Crohn's
disease—as well as 'microscopic colitis'—both collagenous (COC) and lymphocytic colitis …

V. Therapeutic potential of nitric oxide donors and inhibitors

MN Muscará, JL Wallace - American Journal of Physiology …, 1999 - journals.physiology.org
Nitric oxide is a crucial mediator of gastrointestinal mucosal defense, but, paradoxically, it
also contributes to mucosal injury in several situations. Inhibitors of nitric oxide synthesis …

Nitric oxide-modulating agents for gastrointestinal disorders

BJR Whittle - Expert opinion on investigational drugs, 2005 - Taylor & Francis
Almost 20 years after the identification of the biological role of nitric oxide (NO), the full
therapeutic potential of novel agents that mimic the activity of NO or interfere with its …

Nitric oxide in the gut.

AL Salzman - New horizons (Baltimore, Md.), 1995 - europepmc.org
Nitric oxide (NO.) plays a central role in the physiology of the gastrointestinal tract and its
response to critical illness. Potential sources of NO. in the gut include: intrinsic intestinal …

[PDF][PDF] Targeting nitric oxide in the gastrointestinal tract

G Dijkstra, H van Goor, PL Jansen… - Current Opinion in …, 2004 - academia.edu
The overall function of the gastrointestinal (GI) tract is to take up nutrients and remove waste.
The major physiologic processes that occur in the GI tract are motility, secretion, digestion …

III. A molecular prelude to intestinal inflammation

MJS Miller, M Sandoval - American Journal of Physiology …, 1999 - journals.physiology.org
Nitric oxide (NO) synthesis is markedly augmented in states of inflammation, largely due to
the expression of inducible nitric oxide synthase (iNOS). Although NO has anti-inflammatory …

New issues about nitric oxide and its effects on the gastrointestinal tract

MJ Martin, MD Jimenez, V Motilva - Current pharmaceutical …, 2001 - benthamdirect.com
Over the last years the important role of nitric oxide (NO) as endogenous modulator of
numerous physiological functions has been shown. NO is involved in the regulation of blood …

Nitric oxide and inflammatory bowel diseases

Guslandi - European journal of clinical investigation, 1998 - Wiley Online Library
Nitric oxide (NO) production, as detectable by indirect and direct methods, as well as the
expression of inducible nitric oxide synthase (iNOS) in the intestinal mucosa appear to be …