Microtubules play crucial roles in cytokinesis, transport, and motility, and are therefore
superb targets for anti-cancer drugs. All tubulins evolved from a common ancestor they …

In eukaryotic cells, microtubules are 24-nm-diameter tubular structures composed of a class
of conserved proteins called tubulin. They are involved in numerous cell functions including …

The structure of the unique bacterial tubulin BtubA/B from Prosthecobacter is very similar to
eukaryotic αβ-tubulin but, strikingly, BtubA/B fold without eukaryotic chaperones. Our …

αβ-Tubulin heterodimers, from which the microtubules of the cytoskeleton are built, have a
complex chaperone-dependent folding pathway. They are thought to be unique to …

The cellular functions of the microtubule (MT) cytoskeleton range from relatively simple to
amazingly complex. Assembled from tubulin, a heterodimeric protein with α-and β-tubulin …

Tubulins are present in all eukaryotes, and the microtubules (MTs) assembled from them are
remarkably similar in all locations and all species: a curved sheet of 13 (sometimes 12-15) …

Microtubules, the dynamic, yet stiff hollow tubes built from αβ-tubulin protein heterodimers,
are thought to be present only in eukaryotic cells. Here, we report a 3.6-Å helical …

Tubulins, the protein constituents of the microtubule cytoskeleton, are present in all known
eukaryotes but have never been found in the Bacteria or Archaea. Here we report the …

The αβ-tubulin dimer assembles into microtubules, essential polymers in all eukaryotic cells.
Microtubules are highly dynamic, a property that derives from tubulin's GTPase activity. Both …

Microtubules are long, slender polymers of αβ-tubulin found in all eukaryotic cells. Tubulins
associate longitudinally to form protofilaments, and adjacent protofilaments associate …